A 2010 article published in Journal of Orthopaedic Research by YM Kwon et al. titled “Lymphocyte proliferation responses in patients with pseudotumors following metal-on-metal hip resurfacing arthroplasty.” studied “the incidence and level of metal-induced systemic hypersensitivity in patients” who underwent metal-on-metal hip resurfacing arthroplasty (MoHRA), “both with and without pseudotumor by measuring lymphocyte proliferation responses to metals.”

The study including 92 patients in all, researchers found that “A higher incidence and level of enhanced lymphocyte reactivity only to [the metal nickel] was found in patients with MoMHRA compared to the patients without MoM implants, reflecting exposure and immune reactivity.”

Interestingly, these researchers found that ion levels of cobalt, chromium, and nickel did not differ much between patients with pseudotumors and those without, suggesting that “systemic hypersensitivity type IV reactions, as measured by lymphocyte proliferation response to these metals, may not be the dominant biological reaction involved in the occurrence of the soft tissue pseudotumors.”

Unfortunately, DePuy Orthopaedics, Inc., the manufacturer of the DePuy ASR and DePuy ASR XL hip replacement systems, has failed time and again to warn users of the risks associated with the DePuy ASR systems.  As a result of this, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used a DePuy ASR hip replacement and suffered premature device failure or another ASR complication as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR hip replacement lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.  Call today and see how we can help.

(855)  452 – 5529


Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.