In 2012, C.M. Nijenhuis and a team from University of Groningen (Groningen, The Netherlands) published a study titled “Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review.” in British Journal of Clinical Pharmacology. There, the link between gestational exposure to selective serotonin reuptake inhibitor drugs (SSRIs) and poor birth outcomes was further explored.
The team states “The increase in selective serotonin re-uptake inhibitor (SSRI) use during pregnancy, questions concerning abnormal development of the enteric nervous system (ENS), increase in laxative use in children and the association of fluoxetine with infantile hypertrophic pyloric stenosis (IHPS) gave rise to this pharmacological literature review.”
“The literature study showed that SSRIs may influence the development of the ENS in two ways. Blockage of the serotonin re-uptake transporter (SERT) during foetal development could influence migration, differentiation and survival of cells. This could lead to abnormal development in the first trimester of pregnancy.” (emphasis added)
For clarity, “5-HT” is scientific shorthand for serotonin. The team continues, “5-HT seems to be a growth factor in the primitive ENS. This growth factor like action is mediated through the 5-HT(2B) receptor and stimulation of this receptor by SSRIs influences the fate of late-developing enteric neurons. This could lead to abnormal development in the second and third trimester.” (emphasis added)
Due to the fact that the manufacturers of many SSRI drugs have failed time and again to provide adequate warning to women using their drugs during pregnancy, SSRI birth defect lawsuits have been filed by the thousands around the world.
If you or a loved one used SSRIs and gave birth to a child with a birth defect or who suffered complications, your family may be entitled to significant financial compensation. For a free, no-obligation case consultation, contact our team of SSRI birth defect lawyers at the information provided below. We have the compassion, experience, and resources required to win the justice you deserve. Call today and see how we can help.
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