Over the last decade or so, a number of articles have been published concerning the link between the use of the atypical antipsychotic drug Risperdal (risperidone) and elevated prolactin levels, ensuing gynecomastia.  (Prolactin is the hormone responsible for breast development and milk production.)

Here, we will discuss one such article, published in a 1999 edition of Journal of Clinical Psychopharmacology.  Titled “Prolactin levels and adverse events in patients treated with risperidone.”, this study by DL Kleinberg et al. reviewed two large then-recent studies that included 841 and 1,884 patients each.  These studies compared patient blood prolactin levels with the occurrence of “six adverse events possibly associated with increased prolactin levels”: “amenorrhea, galactorrhea, and decreased libido in women; erectile dysfunction, ejaculatory dysfunction, gynecomastia, and decreased libido in men”.

With statistical analysis, the study team found “Both risperidone and haloperidol produced dose-related increases in plasma prolactin levels in men and women.”  Further, it was determined that “Among men, the incidence of adverse events was positively correlated with risperidone dose”.

Due to the fact that Janssen Pharmaceuticals, Inc. (the manufacturer of Risperdal) has failed time and again to adequately warn male users of the risk for gynecomastia associated with Risperdal, many affected users have chosen to file Risperdal lawsuits with great success.  If you or a loved one used Risperdal and suffered male breast growth as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, resources, and skills required to win the compensation you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

In 2003, the results of a small study titled “Risperidone-associated hyperprolactinemia: evaluation in twenty psychiatric outpatients.” by S. Brunelleschi were published in Psychopharmacological Research (the official journal of the Italian Pharmacological Society), aiming to elucidate a potential link between use of Risperdal (risperidone) and hyperprolactinemia (elevated prolactin levels).  For clarity, prolactin is the hormone responsible for breast development and milk production.  In males, elevated prolactin levels can lead to gynecomastia – male breast growth, which can be very troublesome.

Explaining their research, the study team wrote “We decided to evaluate the effects of risperidone on serum prolactin levels and prolactin-related adverse effects in 20 outpatients of an Italian community psychiatric service. Patients enrolled in this study were on risperidone (2-8 mg per day; mean dose=4.15+/-0.4 mg per day) treatment in the period May-November 2002. The 20 patients, 13 women and 7 men (mean age=36.38+/-3.2 years for women and 29.7+/-2.2 for men) who accomplished inclusion criteria, participated in the study after giving informed written consent.”

Results showed that “Raised prolactin levels were observed in 13 (9 women and 4 men) out of 20 patients, but only 8 patients presented prolactin-related adverse effects, libido reduction being the most frequent.”  This study demonstrating that “risperidone enhanced serum prolactin in 65% of patients” could be used as evidence in a Risperdal lawsuit to demonstrate to court that the manufacturer of Risperdal knew, or should have known the risks associated with its product.

As such, if you or a loved one used Risperdal and suffered gynecomastia or another complication, you too may be entitled to significant financial compensation for your injury and undue suffering.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, experience, and resources required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

In 2010, a team of researchers led by N. Yasui-Furukori et al. published the results of a study titled “Gender-specific prolactin response to antipsychotic treatments with risperidone and olanzapine and its relationship to drug concentrations in patients with acutely exacerbated schizophrenia.” in Progress in Neuro-psychopharmacology & Biological Psychiatry that aimed to determine the extent of the relationship between risperidone (Risperdal) and elevation of prolactin levels.

Prolactin is a hormone responsible for breast development and milk production, and as such, elevations of prolactin in males can cause gynecomastia – male breast development, a condition that can be very troubling.

This study reviewed 94 patients suffering from schizophrenia (46 males, 48 females) who were prescribed either olanzapine (Zyprexa) or risperidone (Risperdal).  Each week for four weeks, their prolactin levels tested.  Results showed that both drugs elevated prolactin levels, but not equally.  Researchers write “Prolactin levels were significantly higher in females than in males at all sampling points in both treatments,” but “Risperidone increased prolactin significantly more than did olanzapine in both males and females.”

Further, the study states that “analyses showed that [change in] prolactin during risperidone was significantly correlated with gender … and age”.

Due to the fact that Janssen Pharmaceuticals, Inc., the manufacturer of Risperdal has failed time and again to inform users of the link between Risperdal use and gynecomastia, a number of Risperdal male breast growth lawsuits have been filed.  If you or a loved one used Risperdal and suffered gynecomastia or another complication, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

In 2005, a team of Polish researchers published a study titled “Prolactin secretion disturbances in schizophrenic patients treated with 2nd generation antipsychotics–risperidone and olanzapine” in Psychiatria Polska that aimed to further elucidate the connection between the use of second-generation antipsychotics and elevation of prolactin.  Prolactin is a hormone in the body responsible for breast development and milk production, and elevation of prolactin – a condition called hyperprolactinemia – can lead to gynecomastia, the development of breasts in men.

As such, this team “[compared] the prevalence of hyperprolactinemia and its clinical symptoms in three groups: (1) patients with schizophrenia treated with risperidone, (2) those treated with olanzapine and (3) the control group.”  In all, 60 schizophrenic patients were studied (26 treated with Risperdal, 34 treated with Zyprexa), and the prolactin levels in these patients were compared to 38 healthy, non-medicated patients.

Researchers found that “Hyperprolactinemia was established in 92.3% patients treated with risperidone and in 76.5% patients treated with olanzapine and in 2.6% subjects of the control group”, drawing a clear connection between risperidone (Risperdal) use and hyperprolactinemia, and between Zyprexa use and hyperprolactinemia.

Sadly, the manufacturer of Risperdal (Janssen Pharmaceuticals, Inc.) has failed time and again to warn users of the risk for hyperprolactinemia and gynecomastia associated with Risperdal use.  As a result, a number of Risperdal lawsuits are currently being filed.  If you or a loved one used Risperdal and suffered gynecomastia as a result, you too may be entitled to significant financial compensation for your undue injury and suffering.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

A 2006 piece published in Neuroendocrinology Letters by M. Kopecek et al. titled “Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia.” states “Risperidone in antipsychotic doses induces hyperprolactinemia” and aims to “verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics.”  That is, the study acknowledges that Risperdal (risperidone) is known to raise levels of prolactin – the hormone responsible for breast development and milk productions – and wanted to test if adding even a very small amount of the drug to a patient’s normal prescription of another antipsychotic would have the same effect.  The condition characterized by dramatically-elevated prolactin levels is called “hyperprolactinemia”.

Admittedly, this was a small study, including only 12 patients who used risperidone “as an augmentation treatment to antidepressants (n=8), anxiolytics (n=6) and mood stabilizers (n=2)”.  However, the results were clear: “11 of 12 patients had hyperprolactinemia.”

Researchers continue, stating a “Significant correlation between risperidone daily dose and plasma prolactin level … was detected” and “Two women suffered from galactorrhea and one from amenorrhea.” (hyperlinks added)

As such, researchers concluded that “Even low doses of risperidone used as an augmentation to antidepressants or benzodiazepines are associated with hyperprolactinemia and can induce endocrinological side effects”, stating that “The co-medication of antidepressants and benzodiazepines can potentially increase intensity of prolactinemia.”

Due to the fact that the manufacturer of Risperdal (risperidone) has failed time and again to adequately warn users of the risk for hyperprolactinemia and potential gynecomastia associated with Risperdal use, a number of Risperdal lawsuits have been filed.  If you or a loved one used Risperdal and suffered these or other complications as a result, you too may be entitled to significant financial compensation for you undue injury and suffering.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

In 2005, a team of researchers led by JA Hellings published a report titled “Risperidone-induced prolactin elevation in a prospective study of children, adolescents, and adults with mental retardation and pervasive developmental disorders.” that aimed to determine if Risperdal (risperidone) caused elevated prolactin levels in females more than males.  Elevated prolactin levels (hyperprolactinemia) may result in a number of side effects including gynecomastia and galactorrhea.

The authors write “In this relatively long-term study of risperidone efficacy and safety for aggression and self-injury in children, adolescents, and adults with [mental retardation] and [pervasive developmental disorders], serum prolactin was measured in a 21-subject subset during the course of a double-blind, placebo-controlled trial.”

Results showed that prolactin levels increased in children and adolescents by more than double after taking Risperdal, and prolactin levels increased in adults about eight-fold.  It was indeed determined that females suffered greater prolactin elevation than men.

Sadly, Janssen Pharmaceuticals, Inc., the company that makes Risperdal, has failed time and again to clearly warn its users that Risperdal use is associated with gynecomastia and other serious complications.  As a result, a number of Risperdal lawsuits are currently being filed.

If you or a loved one used Risperdal and suffered gynecomastia or another complication as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, experience, and resources required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

In 2005, a report by JR Stevens et al. published in Journal of Child and Adolescent Psychopharmacology and titled “Elevated prolactin levels in male youths treated with risperidone and quetiapine.” aimed to determine the extent to which Risperdal (risperidone) and Seroquel (quetiapine) raised levels of prolactin in patients.  Prolactin is the hormone responsible for breast growth and milk production, and many studies have been published linking Risperdal and male breast growth.

“The aim of this study was to report on the serum prolactin levels in 70 male youths at a residential treatment center who were treated with either risperidone or quetiapine.”  Fifty of those patients were treated with Risperdal, and twenty were treated with Seroquel.

After six weeks, it was found that “Prolactin was above the upper limit of normal for 68% of the patients on risperidone and 20% of the patients on quetiapine”.  As such, this paper concluded that “Given that hyperprolactinemia secondary to antipsychotic treatment may result in reproductive and growth irregularities, periodic long-term monitoring during treatment with these two atypical antipsychotics (and perhaps others as well) may be warranted.”

Due to the fact that Janssen Pharmaceuticals, Inc. (the manufacturer of Risperdal) has failed time and again to warn users of the risk for male breast growth with Risperdal, a number of Risperdal lawsuits are currently being filed.

If you or a loved one used Risperdal and suffered male breast growth as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, please contact our team of Risperdal lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

A 2001 paper by G. Masi et al. published in Journal of Child and Adolescent Pharmacology begins its abstract as follows: “Although hyperprolactinemia is a common side effect during risperidone treatment in adult patients, no information is available on young children.”

To be clear, hyperprolactinemia is a condition characterized by elevated blood levels of prolactin, the hormone responsible for breast development and milk production.  As such, one negative side effect of this condition is gynecomastia – male breast growth, an ailment that can be very detrimental to a patient’s psychology, especially in children.

The title of this paper was “Prolactin levels in young children with pervasive developmental disorders during risperidone treatment.” and understandably, aimed to “report on serum prolactin levels in 25 young autistic children (22 males and 3 females, age range 3.9-7 years, mean age 4.10 years) during treatment with risperidone (dosage range 0.25-0.90 mg/day, mean dosage 0.52 mg/day).” (hyperlinks added)

Blood levels of prolactin were tested after these children used risperidone (Risperdal) for 10 weeks.  Results showed that while “Six children (24%) showed prolactin levels lower than 15 ng/mL, which is the upper normal level; eight children (28%) had prolactin levels higher than two times the upper limit (30 ng/mL).” (emphasis added)

Unfortunately, the manufacturer of Risperdal has failed to adequately warn users of the risk for hyperprolactinemia and ensuing gynecomastia, and accordingly, a number of Risperdal lawsuits have been filed.  If you or a loved one used Risperdal and suffered male breast growth or another complication as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the experience, resources, and compassion required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

A paper published in 2005 by K. Melkersson in Journal of Clinical Psychiatry titled “Differences in prolactin elevation and related symptoms of atypical antipsychotics in schizophrenic patients.” aimed to evaluate the degree to which different atypical antipsychotic drugs elevated blood levels of prolactin (the hormone responsible for breast growth and milk production) in a group of patients suffering from schizophrenia.  The drugs tested in this study were clozapine (Clozaril), olanzapine (Zyprexa), and risperidone (Risperdal).

Since the FDA cleared Risperdal for the treatment of psychotic symptoms in 1993, many studies have been published linking Risperdal and male breast growth – gynecomastia, a side-effect of elevated prolactin levels.

In all, 28 patients using Clozaril, 29 using Zyprexa, and 18 using Risperdal were studied.  Though this was an admittedly small study, statistically-significant results were found.

First, “Elevated PRL levels were found in 16 (89%) of the patients receiving risperidone and in 7 (24%) of the patients receiving olanzapine, but in none of the patients receiving clozapine.”  For clarity, “PRL” means prolactin levels.

And next, Melkersson found that “Moreover, hyperpro-lactinemic symptoms-menstrual disturbances, galactorrhea, impotence, oligospermia, and decreased libido-were reported in 8 (44%) of the risperidone-treated patients and in 1 (3%) of the olanzapine-treated patients, but in none of the clozapine-treated patients.”

So, the paper concluded that “Treatment with risperidone was frequently associated with hyperprolactinemia and related symptoms, whereas the occurrence of PRL elevation and related symptoms was modest in patients receiving olanzapine and nonexistent in those receiving clozapine.”

Sadly, the Risperdal Warning Label fails to adequately warn users of the risk for gynecomastia associated with this drug.  As such, many Risperdal gynecomastia lawsuits have been filed, seeking compensation from the manufacturer for such undue injury.  If you or a loved one used Risperdal and suffered male breast growth or another complication, you too may be entitled to significant financial compensation.

For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.

In a 2005 report by XY Zhang et al. titled “Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol: a double-blind and randomized study.” published in Psychopharmacology, researchers aimed to “compare the effect of risperidone and haloperidol on serum PRL and investigate the relationship between serum PRL levels and clinical response in patients with schizophrenia.”  For clarity, “PRL” refers to blood levels of prolactin, the hormone responsible for breast development and milk production.  Risperidone (Risperdal) and haloperidol (Haldol) are two commonly-used antipsychotic medications, though historically, Risperdal is more commonly associated than other similar drugs with elevated prolactin levels and consequent gynecomastia – male breast growth.

This report studied 78 schizophrenic patients, “randomly assigned to 12 weeks of treatment with 6 mg/day of risperidone or 20 mg/day of haloperidol after a 2-week washout period”.  When testing prolactin levels, researchers were not aware of which drug each patient had used, nor were patients aware of which drug they were administered.  In this way, this was a “double-blind” study.

Results showed that “Both risperidone and haloperidol treatment significantly increased serum PRL levels in drug-free chronic schizophrenia patients”.  But, “Considering dose-adjusted serum PRL levels, risperidone treatment induced a significant elevation of PRL levels compared with haloperidol treatment at the haloperidol equivalent”.  As such, the team concluded that “Risperidone is associated with a robust effect on prolactin secretion in contrast to the conventional antipsychotic haloperidol” and “Prolactin monitoring during risperidone treatment should be performed.”

Due to the fact that Janssen Pharmaceuticals, Inc., the manufacturer of Risperdal, has time and again failed to notify users of the risk for male breast growth, a number of Risperdal gynecomastia lawsuits have been filed.  If you or a loved one used Risperdal and suffered male breast growth or another negative side effect, you too may be entitled to significant financial compensation.

For a free, no-obligation case consultation, contact our team of Risperdal lawyers at the information provided below.  We have the compassion, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Risperdal Lawsuit Information page is a great place to start if you have any questions about Risperdal.