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Category Archives: Depacon / Depakene / Depakote

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1992 – Research shows danger of VPA therapy during pregnancy

Posted in Depacon / Depakene / Depakote

Around 90 percent of all epileptic women who are on antiepileptic drugs will bear children healthy children with no congenital malformations.  However, antiepileptic drugs do have the ability to cause harm to a developing fetus or embryo and congenital malformations are seen in a higher rate with women exposed to these drugs than is seen… Continue Reading

1991 – UK study shows AEDs increase risk for birth defects

Posted in Depacon / Depakene / Depakote

There are many risks involved with antiepileptic drugs and women of child-bearing age.  Dangerous pregnancies, interference with contraception, and major congenital malformations in the offspring are all factors associated with pregnant epileptics and AEDs.  These adverse effects seen from AEDs are a necessary risk due to the fact that seizures during pregnancy may cause harm… Continue Reading

1993 – Study finds connection between AED therapy and birth defects

Posted in Depacon / Depakene / Depakote

Treatment strategies for effect control over seizures vary for every individual.  A patient should only be prescribed antiepileptic medications after a definitive diagnosis of epilepsy has been made and recurrence rates after a first seizure may vary from 26 and 71 percent.  Author DM Treiman of the Neurology Service at DVA West Los Angeles Medical… Continue Reading

1997 – Study Shows: VPA highly dangerous for developing fetus

Posted in Depacon / Depakene / Depakote

The purpose of study done by researchers from the Department of Clinical Genetics at University Hospital Rotterdam/Dijkzigt, in Rotterdam, The Netherlands, titled “Maternal use of Antiepileptic Drugs and the Risk of Major Congenital Malformations: a Joint European Prospective Study of Human Teratogenis Associated with Maternal Epilepsy”, was to determine the damaging effects that monotherapy and… Continue Reading

Many doctors unaware of the risk for birth defects associated with Depacon

Posted in Depacon / Depakene / Depakote

In the past, medical research has shown that certain antiepileptic drugs that induce Hepatic enzymes lower oral contraceptive sex hormone levels by 40 percent,  and this may lead to an increase of unplanned pregnancies in epileptic women.  There is also a great deal of research that has found a positive correlation between AEDs and the… Continue Reading

Depacon, other AEDs tied to risk for birth defects

Posted in Depacon / Depakene / Depakote

There are many risks involved with AEDs and their potential side effects should be considered during all stages of a child’s maturation.  Birth, pregnancy, breast feeding and older children being treated for epilepsy are all times of possibly coming across dangerous side effects from these drugs.  Epilepsy alone does not show to have harmful effects… Continue Reading

More research highlights the risk for congenital malformations associated with AEDs

Posted in Depacon / Depakene / Depakote

Antiepileptic drugs are associated with a wide range of possible birth defects and major congenital malformations, and it is well documented that the risks for developing MCMs and birth defects are greatly increased when the amount of AEDs a pregnant epileptic woman is taking is increased.  Most doctors would strongly recommend the use of only… Continue Reading

“Effect of Antiepileptic Drugs on Human Placenta and the Fetus” shows risk for birth defects

Posted in Depacon / Depakene / Depakote

All pregnancies are associated with some levels of risk, but women with epilepsy have an increased risk of complications and an increased incidence of major congenital malformations in their offspring.  Antiepileptic drugs are shown to have damaging effects on a developing fetus due to their ability to cross the placenta and reach pharmacologically significant concentrations… Continue Reading

Research from UK highlights risk for birth defects associated with AEDs

Posted in Depacon / Depakene / Depakote

Author N. Adab from the Department of Neurological Science at The Walton Centre for Neurology and Neurosurgery, in Liverpool, UK, wrote an article titled “Therapeutic Monitoring of Antiepileptic drugs During Pregnancy and in the Postpartum Period: is it Useful?”, where he states “As in all patient populations, epilepsy is common in pregnant women. Consequently, approximately… Continue Reading

Connection between cerebral hemorrhage in newborns and maternal AED use found

Posted in Depacon / Depakene / Depakote

The objectives of a study called “The Frequency of Neonatal Morbidity After Exposure to Antiepileptic Drugs in Utero:  A Retrospective Population-Based Study”, written from the Department of Perinatology-Neonatology, Maribor Teaching Hospital in Slovenia, were to determine fetal growth retardation, cerebral hemorrhage, neonatal withdrawal symptoms, and other general malformations in offspring exposed to antiepileptic drugs in… Continue Reading

“Teratogenesis in repeated pregnancies in antiepileptic drug-treated women”

Posted in Depacon / Depakene / Depakote

Today there are many studies available exploring the side effects of antiepileptic drugs (AEDs) taken during pregnancy.  One concern in such cases involves the risk of teratogenesis, which is the malformation of the fetus and/or embryo.  Most studies primarily focus on the initial pregnancy; there is less information available in regards to subsequent pregnancies in… Continue Reading

Danger of AED exposure in utero evaluated

Posted in Depacon / Depakene / Depakote

There are many concerns regarding women of childbearing age who suffer from epilepsy.  There is a clear connection between antiepileptic drugs and their ability to cause harm to a developing fetus or embryo.  Reduced fertility and other menstrual cycle disorders have been linked with exposure to certain antiepileptic drugs.  In an article titled “Teratogenic Potential… Continue Reading

Grim outlook for children exposed to AEDs during pregnancy

Posted in Depacon / Depakene / Depakote

The purpose of a study done by the Faculty of Medicine, University of Rijeka, titled “Epilepsy and Pregnancy: Antiepileptic Drugs Effects on Pregnancy”, was to determine the amount of antiepileptic drugs being used in pregnant women with epilepsy and to analyze possible complications during pregnancy and delivery.  This study was conducted in the University Hospital… Continue Reading

Depacon associated with poor heart development in newborns

Posted in Depacon / Depakene / Depakote

Antiepileptic drugs (AEDs) have shown to increase the risk of major congenital malformations (MCMs) in the offspring of epileptic drugs.  AEDs have shown to have harmful effects on a developing fetus or embryo.  Most doctors would recommend treatment using only one antiepileptic drug, which has shown to have a decreased effect on the rate of… Continue Reading

Fetal hydantoin syndrome associated with in utero AED exposure

Posted in Depacon / Depakene / Depakote

The connection between antiepileptic drugs and their ability to cause damage to a developing fetus or embryo is well documented.  Antiepileptic drugs (AEDs) are clearly connected to an increased risk of major congenital malformations in offspring exposed to the drugs during development.  Author Oguni M, from the Department of Pediatrics, Tokyo Women’s Medical University, at… Continue Reading

Depacon, AEDs found to be highly dangerous for developing children

Posted in Depacon / Depakene / Depakote

The connection between antiepileptic drugs and their ability to cause harm to a developing fetus or embryo has been well documented in the medical world.  Many doctors would advise their epileptic patients’ to be on as few antiepileptic drugs (AEDs) as possible.  This is especially important for epileptic women who are trying to conceive.  Author… Continue Reading

Depacon, antiepileptic drugs dramatically raise risk for birth defects

Posted in Depacon / Depakene / Depakote

Antiepileptic drugs (AEDs) are associated with a wide range of side effects, and the increased risk of major congenital malformations (MCM) to the offspring of women exposed to AEDs during pregnancy is very well known.  In a study called “Factors Influencing the Risk of Abnormal Pregnancy Outcome in Epileptic Women: A Multi-centre Prospective Study”, done… Continue Reading

AEDs, not maternal epilepsy, responsible for birth defects

Posted in Depacon / Depakene / Depakote

Some studies have shown that women with epilepsy have an increased risk for bearing children with major congenital malformations.  And, it has been shown many times that in utero exposure to maternal antiepileptic drugs (AEDs) exacerbates that risk.   The study described below aimed to clarify whether it was maternal epilepsy or in utero exposure to… Continue Reading

Depacon (sodium valproate) linked to spina bifida, other neural tube defects

Posted in Depacon / Depakene / Depakote

Maternal use of antiepileptic drugs is well-known to be associated with elevated risks of major congenital malformations in offspring.  When compared to the general public, the risk for congenital malformations in the offspring of women on antiepileptic medication is roughly 4 to 6 percents, twice as likely as women not on AEDs.  Author Yerby MS… Continue Reading

Research shows: Antiepileptic drugs linked to birth defects

Posted in Depacon / Depakene / Depakote

Epilepsy in women comes with many potential effects on fertility, reproduction, menstrual cycle and sexual development.  Both the disease, and the medications prescribed can have negative effects on a woman’s menstrual cycle and fertility; antiepileptic drugs increase the risk of major congenital malformations (MCMs) in the offspring of women with epilepsy. Author Crawford P. from… Continue Reading

Depacon and similar AEDs connected to serious birth defects

Posted in Depacon / Depakene / Depakote

Carefully and closely-monitored clinical management is extremely important for epileptic women who are trying to become pregnant, for an epileptic woman’s ‘seizure frequency’ or patterns may change during the course of her pregnancy.  Seizure activity and the mothers’ exposure to antiepileptic drugs can cause damage to a developing fetus or embryo.  Author Pack AM. From… Continue Reading

“Guidelines for Care of Women with Epilepsy” warns: AEDs dangerous for fetus

Posted in Depacon / Depakene / Depakote

The harmful effects that antiepileptic drugs may have on a developing fetus are well-known.  Many studies have shown with quite certainty that the amount of antiepileptic drugs (AEDs) a mother uses during her pregnancy is correlated with an increased risk for major congenital malformations (MCMs) in her children.  For this reason alone, most doctors would… Continue Reading