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Category Archives: Depacon / Depakene / Depakote

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Huge increase in birth defect risk with prenatal Depacon, AED exposure

Posted in Depacon / Depakene / Depakote

Titled “Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.”, a study by K. Wide et al. (2004) further demonstrates knowledge in the medical community that in utero exposure to antiepileptic drugs (AEDs) containing valproate (Depacon, Depakene, Depakote, and others) is linked… Continue Reading

2003 – In Utero AED Exposure Linked to Birth Defects Far Above Background Rate

Posted in Depacon / Depakene / Depakote

In September, 2003, a team from St. Vincent’s Hospital (Melbourne, Australia) published a piece in Journal of Clinical Neuroscience titled “The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.”  That article, by F.J. Vajda et al., further explored the risks of prenatal exposure to antiepileptic drugs containing valproate, such as Depacon, Depakene,… Continue Reading

1999 – Researchers find Depacon, Depakene, and Depakote linked to major congenital abnormalities

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Published in a 1999 edition of Annals of Neurology, an article by E.B. Samrén et al. titled “Antiepileptic drug regimens and major congenital abnormalities in the offspring.” provides important insight into the risks of prenatal exposure to antiepileptic drugs (AEDs), something that has been demonstrated to greatly increase the rate of spina bifida, other neurological… Continue Reading

Prenatal exposure to Depacon, Depakene, Depakote linked to lower intelligence in children

Posted in Depacon / Depakene / Depakote

Over the past ten years or so, dozens of studies have been published linking prenatal exposure to the antiepileptic drugs Depacon, Depakene, and Depakote (Abbott Laboratories, Inc.) with birth defects.  Here, I will summarize one such study, published by R. Banach and a team from McMaster University in Ontario Canada.  This study was titled “Long-term… Continue Reading

1997 – Team finds Depacon / Depakene / Depakote to lift malformation risk up to 700%

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Back in 1997, a team of Dutch medical researchers led by E.B. Samrén published an article titled “Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy.” in Epilepsia.  That article aimed to “To quantify the risks of intrauterine antiepileptic drug… Continue Reading

Birth defects risk 2-3 times higher with Depacon exposure

Posted in Depacon / Depakene / Depakote

From a team of Swedish researchers, an article appearing in the November, 2009 edition of Neurologic Clinics titled “Teratogenic effects of antiepileptic medications.” provides important insight into the connection between prenatal exposure to epilepsy drugs Depacon, Depakene, and Depakote and cardiovascular and neurological birth defects.  Because of a failure to warn, class-action Depacon lawsuits have… Continue Reading

2011 – Depakote only drug to lift birth defect risk in polytherapy

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A study titled “Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations.” by L.B. Holmes and a team from MassGeneral Hospital for Children (Boston, MA) published in the October, 2011 edition of Archives of Neurology further explores the link between in utero exposure to epilepsy drugs containing valproate (Depacon and other drugs by… Continue Reading

New England Journal of Medicine: Depacon Causes Defects, Decreased Cognitive Function

Posted in Depacon / Depakene / Depakote

Titled “Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.”, an article by K.J. Meador and a team from Emory University published in the April, 2009 edition of New England Journal of Medicine provides further insight into the adverse effects of prenatal exposure to antiepileptic drugs containing valproate, the active chemical… Continue Reading

Depacon, Depakote, and Depakene carry risk for birth defects at 6.7%

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In February of this year, E. Campbell and a team from Royal Victoria Hospital (Belfast, UK) published a piece in Journal of Neurology, Neurosurgery, and Psychiatry titled “Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.” further demonstrating the link between exposure to maternal epilepsy… Continue Reading

Reduced cognitive ability linked to prenatal Depacon / Depakene / Depakote exposure

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In March, 2013, a medical research team led by K.J. Meador published an article in Lancet Neurology titled “Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.”.  This team from Emory University (Atlanta) aimed to “We aimed to assess effects of commonly used antiepileptic drugs on cognitive… Continue Reading

Depakote linked to birth defects, poor neonatal development

Posted in Depacon / Depakene / Depakote

In recent years, a number of independent medical research teams have determined that prenatal exposure to antiepileptic drugs branded Depacon, Depakene, and Depakote is linked to increased risk for birth defects.  Here, I will discuss research from one such team led by G. Veiby of The University of Bergen, Norway, specifically, an article titled “Pregnancy,… Continue Reading

2011 – Depacon, SSRIs advised against during pregnancy citing defects and autism

Posted in Depacon / Depakene / Depakote, Paxil Birth Defects, SSRI Birth Defects

In recent years, a number of studies have demonstrated that Depacon (sodium valproate) use during pregnancy is linked to increased risk for a range of serious birth defects.  This epilepsy drug by Abbott Laboratories, Inc. is often safe, but has been linked to autism, neurological birth defects, heart defects, craniofacial birth defects, and a number… Continue Reading

2011 – Study connects Depakote and neural tube defects

Posted in Depacon / Depakene / Depakote

In November 2011, Emily W.Y. Tung and Louise M. Winn of the Department of Pharmacology and Toxicology at Queen’s University in Ontario, Canada published a study titled “Valproic acid-induced DNA damage increases embryonic p27KIP1 and caspase-3 expression: A mechanism for valproic-acid induced neural tube defects” that studied the mechanism by which valproic acid causes neurological… Continue Reading

2013 – More research published linking Depacon / Depakote / Depake with birth defects

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In a 2013 study published in Reproductive Toxicology by Matteo Cassina et al. titled “Pregnancy outcome in women exposed to antiepileptic drugs: Teratogenic role of maternal epilepsy and its pharmacologic treatment” aimed to further evaluate the connection between valproic acid (the active ingredient in Depacon, Depakene, and Depakote) and serious birth defects. The paper on this… Continue Reading

Depacon, other AEDs found associated with severe congenital malformations

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In 1981, medical researcher F. Majewski, published a study in the Internaltional Journal of Biological Research in Pregnancy titled “The teratogenicity of Hydantoins and Barbiturates in Humans, With Considerations on the Etiology of Malformations and Cerebral Disturbances in the Children of Epileptic Parent”. The study consisted of 194 children from epileptic mothers and 71 children… Continue Reading

1996 – Risk AEDs pose to developing fetus evaluated

Posted in Depacon / Depakene / Depakote

The objectives of a 1996 study done by The Medical Birth Registry of Norway at University of Bergen, in Norway, titled “Spina Bifida and Cleft Lip Among Newborns of Norwegian Women With Epilepsy: Changes Related to the Use of Anticonvulsants”, were to determine the association between the use of anticonvulsants for epileptic women during or… Continue Reading

“Neurologic Care of Pregnant Women with Epilepsy”: AEDs dangerous for fetus

Posted in Depacon / Depakene / Depakote

One common neurologic condition seen in women who are of child-bearing age is epilepsy.  There are many concerns child bearing age women with epilepsy have when it comes to having a safe and healthy pregnancy, however most epileptic women will have a safe pregnancy and carry to term a healthy child.  Author Zahn C., from… Continue Reading

2007 – Connection found between AED use and birth defects

Posted in Depacon / Depakene / Depakote

There is an increased risk that children exposed to antiepileptic drugs in utero will develop major congenital malformations.  Despite these elevated risks, the majority of children exposed to antiepileptic drugs during development will be born free of any abnormal functional neurodevelopment.  Author Meador KJ, from the department of Neurology, Georgetown University Hospital, wrote an article… Continue Reading

Risk for birth defects “2-3 times greater” with in utero exposure to AEDs

Posted in Depacon / Depakene / Depakote

An article titled “The European Registry of Antiepileptic Drugs and Pregnancy”, from the Department of Experimental Neurology, University of Berlin, by Kretz R., et al., states that “All old-generation antiepileptic drugs (AEDs) are considered to be teratogenic. In Germany, one out of 200 pregnant women (0.5%) is treated with AEDs for epilepsy. The risk of… Continue Reading

1992 – Early explorations of the danger AEDs pose to developing babies

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A study done by a team from The Department of Neurology at St. Martino Hospital, in Genoa, Italy, titled “Epilepsy, Pregnancy, and Major Birth Anomalies: an Italian Prospective, Controlled Study”, followed 138 pregnancies, 97 women with epilepsy, and 88 women without epilepsy.  The women were matched for age during 140 pregnancies, and the study evaluated… Continue Reading

2010 – VPA (Depacon) Associated with 14 Congenital Malformations

Posted in Depacon / Depakene / Depakote

Some  studies suggest that the use of certain antiepileptic medications such as valproic acid (Depacon / Depakene / Depakote) in the first trimester is associated with an increased risk of spina bifida.  Limited information is available on the risks of other congenital malformations.  A study done by a team from the Department of Pharmacoepidemiology and… Continue Reading

2007 – Depacon, other AEDs demonstrated to be dangerous for fetus

Posted in Depacon / Depakene / Depakote

There is a clear understanding of the  harmful effects that antiepileptic drugs (AEDs) can have on a developing fetus or embryo; the medical community is pretty much done debating, and it is widely-accepted in medical literature that exposure to AEDs during development increases the risk of major congenital malformations (MCMs) in the fetus.  Some of… Continue Reading