A 2011 article by YM Kwon et al. titled “‘Asymptomatic pseudotumors after metal-on-metal hip resurfacing arthroplasty: prevalence and metal ion study.” published in The Journal of Arthroplasty cites that “Symptomatic abnormal periprosthetic soft-tissue reactions (“pseudotumors”) have been reported after metal-on-metal hip resurfacing arthroplasty (MoMHRA).”

Accordingly, the aims of this study were twofold: “(1) to determine the prevalence of asymptomatic pseudotumors after MoMHRA and (2) to measure metal ion levels in these patients.”  And to that end, researchers studied 201 metal-on-metal hip replacements (in 158 patients) over a period of time (average follow-up length just over 5 years) using ultrasound and MRI to see the implanted hips, and “serum/hip aspirate cobalt and chromium measurements” to determine metal ion levels in the blood.

After analyzing their data, Kwon et al. (2011) found that “Pseudotumors found in 7 patients (4%) were associated with significantly higher cobalt and chromium levels and inferior functional scores” and “Elevated levels of cobalt and chromium ions suggest that pseudotumors are associated with increased wear generated from metal-on-metal articulations.” (emphasis added)

Concluding, researchers wrote “Clinicians need to be aware of pseudotumors as a differential diagnosis during clinical evaluation of MoMHRA patients, and further imaging such as ultrasound or magnetic resonance imaging is recommended to confirm the diagnosis.”

Sadly, the manufacturer of  the ASR / ASR XL metal-on-metal hip replacement systems, DePuy Orthopaedics, Inc., failed time and again to adequately warn users of this risk.  As such, many DePuy ASR lawsuits are currently being filed.  If you or a loved one used a DePuy metal-on-metal hip replacement and suffered these or other negative side effects as a result, you too may be entitled to significant financial compensation for your undue injury.

For a free, no-obligation case consultation, contact our team of DePuy ASR hip replacement lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

In a 2011 article by NP Hailer et al. titled “Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty.” published in the medical journal Acta Orthopaedica, researchers state “Following metal-on-metal hip arthroplasty (THA), immunological reactions including changes in lymphocyte populations, aseptic loosening, and lymphocytic pseudotumors occur” and hypothesized “that changes in lymphocyte subpopulations would be associated with elevated metal ion concentrations.”

Studying 85 patients who underwent total hip arthroplasty – 41 patients receiving metal-on-metal implants and 44 using metal-on-polyethylene implants, researchers evaluated blood levels of chromium and cobalt, and “Leukocyte subpopulations and immunoglobulins in patient blood were measured using standard laboratory methods.”

After analysis, authors of this paper found that “Patients with a metal-on-metal hip had higher serum concentrations of chromium … and cobalt … than those with metal-on-polyethylene.”  Further, indicators of pseudotumors (elevated HLA DR(+), CD8 T-cell counts) were “higher in the metal-on-metal group” and “correlated positively with chromium and cobalt concentrations in patient blood”.

As such, Hailer et al. (2011) concluded that “immunological alterations appear to be associated with increased cobalt and chromium concentrations” and state “It is tempting to speculate that HLA DR(+) CD8(+) T-cells are involved in the pathogenesis of allergic reactions, implant loosening, and lymphocytic pseudotumors.”

Due to the fact that DePuy Orthopaedics, Inc., the manufacturer of the popular (and recently-recalled) ASR metal-on-metal hip replacement systems failed time and again to warn users of these risks, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used a DePuy ASR hip replacement and suffered premature device failure, or one of these or other side effects as a result, you may be entitled to significant financial compensation for your injuries.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

In a 2011 report by AJ Hart et al. published in Clinical Orthopaedics and Related Research, researchers write “Many factors affect the blood metal ion levels after metal-on-metal (MOM) hip arthroplasty” and “The main surgically adjustable variable is the amount of coverage of the head provided by the cup which is a function of the inclination and version angles.”

However, the team notes that “most studies have used plain radiographs which have questionable precision and accuracy” and accordingly, states that “the relationship between version and blood metal ions levels has not been resolved.”

To determine “whether cup inclination and version influence blood metal ion levels,” this research team studied 100 patients who had a metal-on-metal hip replacement, and reviewed “clinical assessment[s], CT scanning, and blood metal ion measurement[s]” for these individuals.

Using a statistical analysis method called regression analysis, Hart et al. (2011) found that “Only cup inclination, version angles, and gender influenced blood cobalt or chromium levels” in the blood, and that “Cobalt and chromium levels positively correlated with inclination angle and negatively correlated with version angle.”

Concluding that their research suggested “insufficient cup version can cause high blood metal ions after MOM hip arthroplasty”, the Hart et al. (2011) research is very important.  A great deal of research has been published in the last decade showing that metal-on-metal hip implants may leak metal ions into the blood, posing a variety of health risks, and any methods for reducing the leaking of metal ions into the blood are invaluable.

Sadly, DePuy Orthopaedics, Inc., a major manufacturer of metal-on-metal hips such as the recently-recalled ASR / ASR XL hip replacement systems, failed time and again to warn users of this risk and the risk for premature device failure associated with their devices.  As a result of this failure to warn, even in light of the number of publications demonstrating the danger associated with the DePuy ASR hip replacement systems, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used an ASR hip replacement and suffered elevated blood metal ion levels or premature ASR failure, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help!

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

In 2008, a paper by A.J. Hart et al. was published in the medical journal Hip International that explains “A cup inclination angle greater than 45 degrees is associated with increased wear rates of metal on polyethylene (MOP) hip replacements,” but that “The same maybe true for metal on metal (MOM) hips yet this has not been clearly shown.”

Determining specific orientations of metal-on-metal hip replacement components that contribute to wear or can lead to lower rates of wear are important because metal particles can wear off from metal-on-metal implants and lead to kidney and liver damage, severe skin irritation (hypersensitivity), pseudotumors, and increased cancer mortality.

And in fact, this team did find orientations of metal-on-metal hip replacement components observed to lead to less wear: “We identified a threshold level of 50 degrees cup inclination. Below this threshold, the mean whole blood cobalt and chromium were 1.6 ppb and 1.88 ppb respectively; above this threshold, the mean blood cobalt and chromium were 4.45 ppb and 4.3 ppb respectively.” (For clarity, “ppb” means parts per billion, and is one of many ways to measure the concentration of metal ions in blood.  This method is also used to determine the concentration of pollutants in water and the air.)

Finding that, “All patients above the threshold had metal levels greater than any of the patients below the threshold”, Hart et al. write “Additionally, our new analytical methods may allow blood metal levels to be used as a realistic biomarker of in vivo wear rate of MOM hips” and “The implication is that metal levels can be minimised with optimal orientation of the acetabular component.”

Due to the fact that DePuy Orthopaedics, Inc., the manufacturer of the popular ASR / ASR XL metal-on-metal hip replacement systems, has failed time and again to adequately warn users of the risk of elevated blood metal ion levels and premature device failure associated with the ASR, a number of DePuy ASR hip replacement lawsuits are currently being filed.

If you or a loved one used a DePuy ASR hip replacement system that failed or resulted in complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the skills, resources, and experience required to win the justice you deserve.

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

In 2006, the government-mandated Canadian organization Health Quality Ontario published the results of a study in Ontario Health Technology Assessment Series that aimed to “assess the safety and effectiveness of metal on metal (MOM) hip resurfacing arthroplasty for young patients compared with that of total hip replacement (THR) in the same population.”

This study, titled “Metal-on-Metal Total Hip Resurfacing Arthroplasty: An Evidence-Based Analysis.” is one of many studies that show the danger of metal-on-metal hip replacements published in the last decade or so.

Reviewing a number of other studies on metal-on-metal hip replacements and the outcomes of total hip resurfacing arthroplasty procedures, this team found that revision (failure and replacement) rates for the two procedures were comparable, a finding not often seen in other similar reports (see link above).

However, a good deal of concern was raised in this paper about “about metal wear debris and its systemic distribution throughout the body.”

The authors write, “Detectable metal concentrations in the serum and urine of patients with metal hip implants have been described as early as the 1970s, and this issue is still controversial after 35 years. Several studies have reported high concentration of cobalt and chromium in serum and/or urine of the patients with metal hip implants. Potential toxicological effects of the elevated metal ions have heightened concerns about safety of MOM bearings. This is of particular concern in young and active patients in whom life expectancy after implantation is long.”

Due to the fact that a major manufacturer of metal-on-metal hip replacements, DePuy Orthopaedics, Inc., has failed time and again to warn users of these and other side effects associated with its ASR and ASR XL hip replacement systems, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used a DePuy ASR hip replacement system and suffered premature hip failure or another complication, you may be entitled to significant financial compensation for your injuries.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the compassion, resources, and skills required to win the justice you deserve.  Call today and see how we can help!

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

A 2012 report by AJ Smith et al. titled “Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the National Joint Registry of England and Wales.” published in the prominent medical journal The Lancet aimed to “assess if metal-on-metal bearing surfaces lead to increased implant survival compared with other bearing surfaces in stemmed [total hip replacement] and, additionally, if larger head sizes result in improved implant survival.”

Stating that “Some prostheses fail, particularly in younger patients, and need to be revised, most commonly for loosening secondary to wear or dislocation.” and that “Surgeons have tried to address these problems by implanting large diameter metal-on-metal bearing surfaces”, the aims of this report were well placed.

For data, this team analyzed findings of the National Joint Registry of England and Wales on 31,171 stemmed metal-on-metal hip replacements implanted between 2003 and 2011.  After review, the team found that “Metal-on-metal THR failed at high rates” and that “failure was related to head size, with larger heads failing earlier”.

Overall, “5 year revision rates in younger women were 6.1% … for 46 mm metal-on-metal compared with 1.6% … for 28 mm metal-on-polyethylene”, compared to revision rates for ceramic-on-ceramic hips in comparable groups at 3.3% at 5 years’ use.

As such, Smith et al. (2012) concluded that “Metal-on-metal stemmed articulations give poor implant survival compared with other options and should not be implanted” and “All patients with these bearings should be carefully monitored, particularly young women implanted with large diameter heads.”

“Since large diameter ceramic-on-ceramic bearings seem to do well we support their continued use.”

Due to the fact that DePuy Orthopaedics, Inc., the manufacturer of the popular ASR / ASRXL metal-on-metal hip replacement systems (recalled in 2010), failed time and again to warn users of the high rate of failure associated with metal-on-metal hip replacements, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used a metal-on-metal hip replacement, particularly one manufactured by DePuy, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.

Call today and see how we can help!

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

In 2011, an article published by R. Underwood et al. in Journal of Bone and Joint Surgery titled “A comparison of explanted Articular Surface Replacement and Birmingham Hip Resurfacing components.” evaluated the relative safety and efficacy of the DePuy ASR hip replacement as compared to Birmingham Hip Resurfacing components.

In recent years, a number of articles have been published demonstrating the tendency for premature failure of DePuy ASR hip replacements, and Birmingham Hip Resurfacing components have been often used as a safety standard for metal-on-metal hip replacements.

While this study did not find significant differences in blood metal ion levels between the two brands of hip replacements (tiny metal particles have been found to wear off from the metal hip implants, causing a variety of health problems ranging from hypersensitivity to cancer risk), Underwood et al. (2012) found “The Articular Surface Replacement (ASR) hip resurfacing arthroplasty has a failure rate of 12.0% at five years, compared with 4.3% for the Birmingham Hip Resurfacing (BHR).”

These findings came from a retrospective analysis of “66 ASR and 64 BHR explanted metal-on-metal hip replacements with the aim of understanding their mechanisms of failure.”

However, the team did find that “The ASR had a significantly increased rate of wear of the acetabular component (p = 0.03) and a significantly increased occurrence of edge loading (p < 0.005), which can be attributed to differences in design between the ASR and BHR.”

Due to the fact that a number of people have used DePuy ASR hip replacements unaware of the excess risk for premature device failure, many DePuy ASR lawsuits have been filed.  As such, if you or a loved one used a DePuy ASR or DePuy ASR XL hip replacement, you may be entitled to significant financial compensation for your injuries.

For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the compassion, experience, and resources required to win the justice you deserve.

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

Citing that “There is widespread concern regarding the incidence of adverse soft-tissue reactions after metal-on-metal (MoM) hip replacement” and “Recent National Joint Registry data have shown clear differences in the rates of failure of different designs of hip resurfacing,” a study by DJ Langton et al. (2011) aimed to “update the failure rates related to metal debris for the Articular Surface Replacement (ASR)” by DePuy Orthopaedics, Inc..

This study was titled “Accelerating failure rate of the ASR total hip replacement.” and appeared in the August 2011 edition of Journal of Bone and Joint Surgery.

For their study, the Langton et al. (2011) team studied a total of 505 DePuy ASR hips and found “a failure rate of 25% at six years for the ASR resurfacing and of 48.8% for the ASR total hip replacement (THR).”

The researchers note “Of 257 patients with a minimum follow-up of two years, 67 (26.1%)” had higher than normal serum cobalt levels and that “analysis of revised components showed that all patients suffering adverse tissue reactions in the resurfacing group had abnormal wear of the bearing surfaces.”

Sadly, DePuy Orthopaedics, Inc. failed time and again to warn users of the high rate of failure associated with the ASR and ASR XL models and in 2010, both of these metal-on-metal hip replacements were recalled.  As a result of this failure to warn, however, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used a DePuy ASR or DePuy ASR XL hip replacement system, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help!

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

Published in 2012, an article by M. Seppänen et al. titled “Hip resurfacing arthroplasty: short-term survivorship of 4,401 hips from the Finnish Arthroplasty Register.” aimed to determine the short-term reliability of a variety of hip resurfacings used in 4,401 Finnish citizens, as compared to the reliability seen in 48,409  total hip arthroplasty procedures during the same period.

In general, the team found that there was no statistically-significant difference in overall reliability between hip resurfacing and total hip arthroplasty.  However, “Female patients had about double the revision risk of male patients”, “Hospitals that had performed 100 or more HRA procedures had a lower revision risk than those with less than 100 HRAs,” and “Articular Surface Replacement (ASR, DePuy) had inferior outcome with higher revision risk than the Birmingham Hip Resurfacing implant (BHR, Smith & Nephew), the reference implant (RR = 1.8, CI: 1.2-2.7).”

That is, the DePuy ASR hip replacement system was found to be nearly twice as likely to fail than the study’s reference implant, the Birmingham Hip Resurfacing.

Because DePuy failed time and again to warn users that the “ASR had higher revision risk”, a finding of these and many other researchers, the ASR was recalled in 2010 and has prompted a number of DePuy ASR lawsuits.

If you or a loved one used a DePuy ASR hip replacement system and suffered premature device failure or another DePuy ASR complication, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the skills, resources, and experience required to win the justice you deserve.  Call today and see how we can help!

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.

Sadly, the 2012 paper by NM Bernthal et al., “Disappointing short-term results with the DePuy ASR XL metal-on-metal total hip arthroplasty.” lives up to its title.

This paper appears in the April 2012 edition of The Journal of Arthroplasty, and “reports on early failures of the ASR XL (Depuy, Warsaw, Ind) and assesses whether a correlation with cup positioning exists”, studying 70 consecutive metal-on-metal total hip arthroplasty procedures.

Of the seventy DePuy ASR XL hip replacements studied, a staggering 17.1% “required replacement within 3 years”.  The main reason for replacement was pain, but ASRs were also replaced due to loosening and squeaking.

“Three additional THAs noted squeaking, 2 noted grinding, and 3 additional hips had persistent pain” and “In total, 20 (28.6%) of 70 demonstrated implant dysfunction.”

Unfortunately, the team found that all problematic hips were in appropriate orientation, and “failures noted with this design do not correlate to cup placement.”  As such, the team concludes that “The high rate of implant dysfunction at early follow-up suggests serious concerns with the concept of MOM THA with an ultralarge-diameter femoral head paired with a monoblock acetabular cup.”

Due to the fact that DePuy failed time and again to warn users of the high rate failure associated with the ASR and ASRXL hip replacement systems, the DePuy ASR systems were recalled in 2010 and accordingly, a number of DePuy ASR lawsuits have been filed.

If you or a loved one used a DePuy ASR hip replacement and suffered premature device failure or another ASR complication, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of DePuy ASR lawyers at the information provided below.  We have the compassion, resources, and skills required to win the justice you deserve.

Call today and see how we can help!

(855)  452 – 5529

justinian@dangerousdrugs.us

Our DePuy ASR™ / ASR™ XL Hip Replacement Lawsuit Information page is a great place to start if you have any questions about DePuy ASR metal-on-metal hip replacements.