Header graphic for print
Dangerous Drugs & Medical Devices News & Commentary on Prescription Drug & Medical Device Lawsuits

Monthly Archives: July 2014

2003 – AEDs with valproate linked to neurological birth defects

Posted in Depacon / Depakene / Depakote

In a 2003 edition of Epilepsia, a piece titled “Clinical care of pregnant women with epilepsy: neural tube defects and folic acid supplementation.” by M.S. Yerby and a team from North Pacific Epilepsy Research in Portland, Oregon demonstrated that a child’s in utero exposure to maternal antiepileptic drugs (particularly those containing valproate – Depakote, Depakene,… Continue Reading

2013 – Neurological and heart defects linked to Depakote

Posted in Depacon / Depakene / Depakote

A piece by medical researchers led by F.J. Vajda published in Acta Neurol Scand. (October, 2013), titled “Associations between particular types of fetal malformation and antiepileptic drug exposure in utero.” lives up to its title and provides more insight into the link between in utero exposure to epilepsy medication (Depacon, Depakene, and Depakote by Abbott… Continue Reading

2009 – More research links Depakote (and other AEDs) to birth defects

Posted in Depacon / Depakene / Depakote

Appearing in the July-August, 2009 edition of the Spanish medical journal, Neurologia, a piece titled “Malformations and fetal death in the Spanish antiepileptic drug and pregnancy registry: results at 6 years” by M. Martinez Ferri et al. aimed to “study the incidence of major congenital malformations (MCM) /and/or fetal-perinatal death (MFP) and determine his relationship… Continue Reading

2002 – Research shows AED exposure lifts rate of neonatal morbidity and birth defects

Posted in Depacon / Depakene / Depakote

In April, 2002, a team of medical researchers from Aberdeen (UK) led by J.C. Dean published a study titled “Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth.” in Journal of Medical Genetics investigating the link between neonatal and later childhood morbidity “in children exposed to antiepileptic drugs [AEDs] in utero.”… Continue Reading

Depakote, other AEDs again linked to birth defects

Posted in Depacon / Depakene / Depakote

An article appearing in the May, 2010 edition of Epilepsia titled “The teratogenic risk of antiepileptic drug polytherapy.” by F.J. Vajda and a team from Royal Melbourne Hospital and University of  Melbourne (Australia) further explores the connection between antiepileptic drugs containing sodium valproate such as Depacon, Depakene, and Depakote and increased risk for congenital malformations…. Continue Reading

2011 – Depacon, Depakene, Depakote exposure linked to poor language skills

Posted in Depacon / Depakene / Depakote

In February, 2011, C. Nadebaum and a British research team published a piece in Neurology titled “Language skills of school-aged children prenatally exposed to antiepileptic drugs.” that provides important insight into the connection between antiepileptic drugs containing sodium valproate (Depacon, Depakene, and Depakote) and birth defects. Nadebaum et al. (2011) state “Fetal exposure to some… Continue Reading

1992 – Study links Depakote and birth defects

Posted in Depacon / Depakene / Depakote

Back in 1992, a French research team led by C. Dravet published a piece in Neurology titled “Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.” that illuminated risks of prenatal exposure to anti-seizure drugs Depacon, Depakene, and Depakote (Abbott Laboratories).  Since, the US FDA has warned of… Continue Reading

Autism, developmental delay risk raised 300% with SSRI exposure before birth

Posted in SSRI Birth Defects

This past April, a piece by R.A. Harrington and a team from Johns Hopkins Bloomberg School of Public Health published in Pediatrics titled “Prenatal SSRI Use and Offspring With Autism Spectrum Disorder or Developmental Delay.” further illustrates the link between prenatal exposure to selective serotonin reuptake inhibitor drugs (SSRIs) and increased risk for autism and… Continue Reading

Study finds some babies more likely to have SSRI birth defects than others

Posted in SSRI Birth Defects

Last summer, Developmental Psychobiology published a piece by S. Brummelte and a team from University of British Columbia (Vancouver) titled “Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) affect newborn serum reelin levels.” exploring contributing genetic factors to susceptibility for SSRI-induced birth defects.  To-date, a number of studies have shown that in utero exposure… Continue Reading

2005 – Higher rate of birth defects with Depacon in pregnancy

Posted in Depacon / Depakene / Depakote

A 2005 article in Acta Neurologica Scandinavica by F.J. Vajda and a team from University of Melbourne (Australia) titled “Maternal valproate dosage and foetal malformations.” further elucidates the connection between prenatal exposure to antiepileptic drugs like Depacon and birth defects.  Because the manufacturers (Abbott Laboratories) failed to warn women of this risk in light of… Continue Reading

Depacon Doubles Risk for Birth Defects (At Least)

Posted in Depacon / Depakene / Depakote

Another article demonstrating that prenatal exposure to antiepileptic drugs containing valproate like Depacon is associated with birth defects, “Valproate and the risk for congenital malformations: Is formulation and dosage regime important?” was published in the April, 2012 edition of the medical journal Seizure by E. Mawhinney et al. of Belfast, UK. In light of warnings… Continue Reading

2- to 3-fold increase in birth defects linked to Depacon / Depakote / Depakene

Posted in Depacon / Depakene / Depakote

In 2005, a team of researchers from The University of Pavia (Pavia, Italy) published a study in Lancet Neurology titled “Birth defects after prenatal exposure to antiepileptic drugs.”, yet again demonstrating that in utero exposure to Depacon, Depakene, and Depakote (antiepileptic drugs containing valproate) is linked to an increased risk for spina bifida, other neurological… Continue Reading

2012 – Babies with Depakote exposure more likely to have malformations

Posted in Depacon / Depakene / Depakote

Published in the January, 2012 edition of Journal of Clinical Neuroscience, an article by F.J. Vajda titled “Teratogenicity of the newer antiepileptic drugs–the Australian experience.” provides important insight into the connection between valproate-containing antiepileptic drugs such as Depacon, Depakene, and Depakote (Abbott Laboratories) and birth defects including spina bifida and developmental disorders including Autism. Reviewing… Continue Reading

Study links maternal SSRIs and childhood autism

Posted in SSRI Birth Defects

A New England Journal of Medicine article published in December, 2013 by A. Hviid et al. titled “Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism.” demonstrates further the connection between prenatal exposure to a mother’s selective serotonin reuptake inhibitor drugs (SSRIs) and increased risk for congenital malformations and autism. Hviid et… Continue Reading

Depakote raises risk for birth defects 2- to 4-fold

Posted in Depacon / Depakene / Depakote

In recent years, dozens of studies have linked prenatal exposure to the antiepileptic drugs containing valproate (Depacon, Depakene, and Depakote) with birth defects including spina bifida, and developmental disorders such as Autism.  Since the manufacturer of these drugs, Abbott Laboratories, failed time and again to warn women of these risks, Depacon birth defect lawsuits have… Continue Reading

Huge increase in birth defect risk with prenatal Depacon, AED exposure

Posted in Depacon / Depakene / Depakote

Titled “Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.”, a study by K. Wide et al. (2004) further demonstrates knowledge in the medical community that in utero exposure to antiepileptic drugs (AEDs) containing valproate (Depacon, Depakene, Depakote, and others) is linked… Continue Reading

Offspring maladaptive with in utero SSRI epxosure

Posted in SSRI Birth Defects

Today, looking through PubMed Health, a medical literature database curated by the United States National Library of Medicine and The National Institutes of Health, I found another article linking poor neonatal outcomes and  to birth defects prenatal exposure to maternal selective serotonin reuptake inhibitor drugs (SSRIs).  This article, titled “Developmental effects of SSRIs: lessons learned… Continue Reading

2003 – In Utero AED Exposure Linked to Birth Defects Far Above Background Rate

Posted in Depacon / Depakene / Depakote

In September, 2003, a team from St. Vincent’s Hospital (Melbourne, Australia) published a piece in Journal of Clinical Neuroscience titled “The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.”  That article, by F.J. Vajda et al., further explored the risks of prenatal exposure to antiepileptic drugs containing valproate, such as Depacon, Depakene,… Continue Reading

1999 – Researchers find Depacon, Depakene, and Depakote linked to major congenital abnormalities

Posted in Depacon / Depakene / Depakote

Published in a 1999 edition of Annals of Neurology, an article by E.B. Samrén et al. titled “Antiepileptic drug regimens and major congenital abnormalities in the offspring.” provides important insight into the risks of prenatal exposure to antiepileptic drugs (AEDs), something that has been demonstrated to greatly increase the rate of spina bifida, other neurological… Continue Reading

Prenatal exposure to Depacon, Depakene, Depakote linked to lower intelligence in children

Posted in Depacon / Depakene / Depakote

Over the past ten years or so, dozens of studies have been published linking prenatal exposure to the antiepileptic drugs Depacon, Depakene, and Depakote (Abbott Laboratories, Inc.) with birth defects.  Here, I will summarize one such study, published by R. Banach and a team from McMaster University in Ontario Canada.  This study was titled “Long-term… Continue Reading

1997 – Team finds Depacon / Depakene / Depakote to lift malformation risk up to 700%

Posted in Depacon / Depakene / Depakote

Back in 1997, a team of Dutch medical researchers led by E.B. Samrén published an article titled “Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy.” in Epilepsia.  That article aimed to “To quantify the risks of intrauterine antiepileptic drug… Continue Reading

Birth defects risk 2-3 times higher with Depacon exposure

Posted in Depacon / Depakene / Depakote

From a team of Swedish researchers, an article appearing in the November, 2009 edition of Neurologic Clinics titled “Teratogenic effects of antiepileptic medications.” provides important insight into the connection between prenatal exposure to epilepsy drugs Depacon, Depakene, and Depakote and cardiovascular and neurological birth defects.  Because of a failure to warn, class-action Depacon lawsuits have… Continue Reading

2011 – Depakote only drug to lift birth defect risk in polytherapy

Posted in Depacon / Depakene / Depakote

A study titled “Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations.” by L.B. Holmes and a team from MassGeneral Hospital for Children (Boston, MA) published in the October, 2011 edition of Archives of Neurology further explores the link between in utero exposure to epilepsy drugs containing valproate (Depacon and other drugs by… Continue Reading

New England Journal of Medicine: Depacon Causes Defects, Decreased Cognitive Function

Posted in Depacon / Depakene / Depakote

Titled “Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.”, an article by K.J. Meador and a team from Emory University published in the April, 2009 edition of New England Journal of Medicine provides further insight into the adverse effects of prenatal exposure to antiepileptic drugs containing valproate, the active chemical… Continue Reading