June 2014

Over the past two decades, a number of medical research teams have linked SSRI use during pregnancy and birth defects, developmental disorders like autism, and adverse birth outcomes such as neonatal abstinence syndrome.  And, a December 2002 article in American Journal of Psychiatry titled “Outcomes of prenatal antidepressant exposure.” published by a team led by G.E. Simon from The Center of Health Studies (Seattle, Washington) gives more insight into the link between selective serotonin reuptake inhibitors (SSRIs) and birth defects.

This study team writes, “Within a group-model health maintenance organization, all infants with apparent prenatal exposure to tricyclic or selective serotonin reuptake inhibitor (SSRI) antidepressants were frequency matched to an unexposed comparison group by year of birth, maternal age, and mother’s lifetime use of antidepressant drugs and mental health care. A structured blind review of mothers’ and infants’ medical records examined perinatal outcomes, congenital malformations, and developmental delay.”

After careful statistical analyses, G.E. Simon et al. (2002) found that “Exposure to SSRIs was associated with a 0.9-week decrease in mean gestational age, a 175-g decrease in mean birth weight, and a 0.29 decrease in mean Apgar,” concluding simply that “SSRI exposure during pregnancy was associated with earlier delivery and consequent lower birth weight”, “Third-trimester SSRI exposure was also associated with lower Apgar scores” and “Women considering taking SSRIs during pregnancy may balance any higher fetal risk against the risk of persistent or recurrent depression.”

Due to the fact that the manufacturers of many SSRI drugs have failed time and again to adequately warm women of these risks, SSRI birth defect lawsuits are being filed around the world seeking compensation for undue injury to innocent newborns.

If you or a loved one used SSRIs and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of SSRI birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

Over the past two decades, a number of medical research teams have linked SSRI use during pregnancy and birth defects, developmental disorders like autism, and adverse birth outcomes such as neonatal abstinence syndrome.  And, a December 2002 article in American Journal of Psychiatry titled “Outcomes of prenatal antidepressant exposure.” published by a team led by G.E. Simon from The Center of Health Studies (Seattle, Washington) gives more insight into the link between selective serotonin reuptake inhibitors (SSRIs) and birth defects.

This study team writes, “Within a group-model health maintenance organization, all infants with apparent prenatal exposure to tricyclic or selective serotonin reuptake inhibitor (SSRI) antidepressants were frequency matched to an unexposed comparison group by year of birth, maternal age, and mother’s lifetime use of antidepressant drugs and mental health care. A structured blind review of mothers’ and infants’ medical records examined perinatal outcomes, congenital malformations, and developmental delay.”

After careful statistical analyses, G.E. Simon et al. (2002) found that “Exposure to SSRIs was associated with a 0.9-week decrease in mean gestational age, a 175-g decrease in mean birth weight, and a 0.29 decrease in mean Apgar,” concluding simply that “SSRI exposure during pregnancy was associated with earlier delivery and consequent lower birth weight”, “Third-trimester SSRI exposure was also associated with lower Apgar scores” and “Women considering taking SSRIs during pregnancy may balance any higher fetal risk against the risk of persistent or recurrent depression.”

Due to the fact that the manufacturers of many SSRI drugs have failed time and again to adequately warm women of these risks, SSRI birth defect lawsuits are being filed around the world seeking compensation for undue injury to innocent newborns.

If you or a loved one used SSRIs and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of SSRI birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

In June, 2009, Current Psychiatry Reports published an article titled “Selective serotonin reuptake inhibitor use during pregnancy and possible neonatal complications.” by J. Cantor Sackett et al. from The Thomas Jefferson University Hospital in Philadelphia that evaluated the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy.  SSRI drugs are antidepressants such as Prozac, Zoloft, and Paxil that work to regulate serotonin levels in the brain.  Serotonin is a neurotransmitter, a “chemical messenger,” if you will, that plays an important role in mood, sleep, appetite, and fetal development.

Cantor Sackett (2009) writes, “This paper reviews the risks and benefits of using selective serotonin reuptake inhibitors (SSRIs) in pregnant women. The effects of SSRI use on pregnant women and fetuses are discussed, and the need for SSRI treatment is explained. Persistent pulmonary hypertension of the newborn, teratogenic risks of SSRI treatment during pregnancy, neonatal adaptations, and long-term outcomes for children whose mothers used SSRIs during pregnancy are specifically considered. Due to conflicting results from current studies, there are no clear guidelines for SSRI treatment in pregnancy. Patients and doctors must discuss together the risks and benefits of SSRI use during pregnancy and decide on a course of treatment. Potential risks must be balanced against the effects of untreated maternal depression.”

Since many studies have linked persistent pulmonary hypertension of the newborn with prenatal SSRI exposure, a number of SSRI birth defect lawsuits have been filed.  If you or a loved one used SSRIs and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.

For a free, no-obligation case consultation, contact our team of SSRI birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

Today, I found an article titled “Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data.” that originally appeared in the February, 2008 edition of Birth Defects Research.  This insightful piece of research by TF Oberlander and a team of researchers from The University of British Columbia (Vancouver) provides more important insight into the link between exposure to selective serotonin reuptake inhibitor drugs (SSRIs) and adverse birth outcomes such as defects like spina bifida, ventricular septal defect, cleft lip and cleft palate, and developmental disorders such as autism.

Evaluating “Population health data, maternal health, and prenatal prescription records” and comparing them to “neonatal records, representing all live births (British Columbia, Canada, N=119,547) during a 39-month period (1998-2001),” researchers studied the rate of major congenital anomalies (CA) and congenital heart disease (CHD).

Researchers found that “The risk for an ASD was higher following SRI monotherapy compared with no exposure, after adjustment for maternal covariates.”  For clarity, “ASD” here stands for atrial septal defect, a heart defect.

Because so many women have used SSRIs during pregnancy unaware of the risk for heart defects and other adverse birth outcomes, a number of SSRI birth defect lawsuits have been filed.

If you or a loved one used SSRIs and gave birth to a child with a congenital malformation or who had an adverse birth outcome, your family may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of SSRI birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

Titled “Growth and development of tadpoles (Xenopus laevis) exposed to selective serotonin reuptake inhibitors, fluoxetine and sertraline, throughout metamorphosis.,” an article by D.E. Conners and a team from The Department of Environmental Health Science at University of Georgia has demonstrated that Prozac and Zoloft in the water supply can inhibit the development of tadpoles.  While many other researchers have demonstrated that these SSRI drugs cross the human placenta during gestation, imagine what they can do to a developing fetus.  (Actually, you don’t have to imagine it, there are hundreds of peer-reviewed articles out there that show exposure to SSRI drugs is linked to birth defects.  Summaries of many of those articles are available by following the preceding link.)  This present article appeared in the December, 2009 of Environmental Toxicology and Chemistry.

The team writes, “Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed drugs that are present in sewage effluents and surface waters. The objective of the present study was to determine whether low environmentally relevant concentrations of the SSRIs fluoxetine and sertraline could impair growth and development in tadpoles of the African clawed frog (Xenopus laevis) and to evaluate if such effects may be caused by a disruption of the neuroendocrine system.”

Results showed that “Tadpoles were exposed to SSRIs at concentrations of 0.1, 1, and 10 microg/L for 70 d throughout metamorphosis. … Tadpoles exposed to fluoxetine (10 microg/L) and sertraline (0.1, 1, and 10 microg/L) exhibited reduced growth at metamorphosis. Tadpoles exposed to sertraline (0.1 and 1 microg/L) exhibited an acceleration of development as indicated by an increase in the time to tail resorption.”

Conners believes that “The effects of SSRIs on growth and development in tadpoles were likely driven by reduced food intake,” because “Reduced feeding rates were observed in SSRI-exposed tadpoles, and nutritional status can influence growth and development in amphibians via effects on the neuroendocrine system.”

Importantly, it is noted that only Zoloft (sertraline) “was capable of causing developmental toxicity in tadpoles at environmentally relevant concentrations.”  As such, the team concluded that “These data warrant additional research to characterize the risks to human health and wildlife from pharmaceutical exposures.”

If you or a loved one used Prozac (fluoxetine) or Zoloft (sertraline) and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Prozac® birth defect lawyers and Zoloft® birth defects lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

In 2009, S. Alwan and J.M. Friedman, a research duo from the University of British Columbia in Vancouver, published a study titled “Safety of selective serotonin reuptake inhibitors in pregnancy.” in CNS Drugs that provided important insight into the link between gestational exposure to selective serotonin reuptake inhibitor drugs (such as Prozac, Paxil, and Zoloft) and serious congenital malformations.

Because it’s written in plain English and not-so-scientific terms, I have included the abstract below:

“Selective serotonin reuptake inhibitors (SSRIs) are among the most commonly used medications, with a prescription frequency of 2.3% in pregnant women. Although most babies born to women who take SSRIs during pregnancy are normal, there is accumulating evidence that maternal SSRI treatment during pregnancy may cause adverse reproductive outcomes.

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Maternal SSRI treatment during the first trimester has been implicated in increased risks of birth defects, specifically cardiac abnormalities, in the infant, whereas third-trimester treatment has been linked to various neonatal complications, including symptoms of neonatal withdrawal and toxicity, prematurity, low birth weight and persistent pulmonary hypertension of the newborn. Although data on neurobehavioural and long-term cognitive problems among children of women who were treated with SSRIs during pregnancy remain limited, the possibility of such functional abnormalities is an additional concern.

[ ]

On the other hand, untreated maternal depression also carries serious risks for both the mother and the baby, and SSRIs are one of the best available treatments. Thus, pregnant women who require treatment for depression and their physicians often face a difficult choice regarding the use of SSRIs.”

While untreated maternal depression does in fact constitute a serious problem, it is of utmost concern that expecting mothers make informed decisions regarding drug use during pregnancy.  And because the manufacturers of many SSRI drugs have failed time and again to adequately inform women of these risks, a number of SSRI birth defect lawsuits have been filed.

If you or a loved one used SSRIs and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of SSRI birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

Today, I came across an article from the Netherlands by M.K. Bakker published in Pharmacoepidemiology and Drug Safety (August, 2010) titled “Fluoxetine and infantile hypertrophic pylorus stenosis: a signal from a birth defects-drug exposure surveillance study.”, a piece that made great strides in elucidating the connection between prenatal exposure to Prozac (fluoxetine) and serious birth defects.  Here, a link is made between Prozac exposure and infantile hypertrophic pyloric stenosis (IHPS)

The website Medindia.net writes that “Pediatric pyloric stenosis is narrowing of the lower end of the stomach due to thickening of the muscles of the pylorus. The narrowing is up to the extent that milk and other stomach contents cannot pass into the small intestine.”

Bakker et al. (2010) state “We report an association found in a surveillance study which systematically evaluated combinations of specific birth defects and drugs used in the first trimester of pregnancy. … The database of a population-based birth defects registry (birth years 1997-2007) was systematically screened for combinations of drugs and malformations that were disproportionately present compared to the rest of the database.”

Results showed “an association between maternal use of fluoxetine and infantile hypertrophic pyloric stenosis (IHPS)”: about 2% of children with IHPS had been exposed to Prozac before birth, while only 0.2% of children with other malformations had been exposed to Prozac during pregnancy.

Due to the fact that the manufacturers of Prozac have failed time and again to adequately warn users of the risk for birth defects, many women have chosen to file Prozac® birth defects lawsuits.

If you or a loved one used Prozac (fluoxetine) and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Prozac® birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

In July 2010, a team of Lebanese published a study titled “Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence?” in the medical journal Birth Defects Research reviewing a congenital malformation linked to prenatal Prozac (fluoxetine) exposure.  That team, led by C. Farra, was the first to associate goldenhar syndrome with Prozac, though other researchers have demonstrated that a number of different craniofacial birth defects are linked to gestational exposure to selective serotonin reuptake inhibitor drugs.

The Farra team writes, “Goldenhar syndrome, also known as oculo-auriculo-vertebral spectrum, is a complex, heterogeneous condition characterized by abnormal prenatal development of facial structures. We present the occurrence of Goldenhar syndrome in an infant born to a woman with a history of prenatal Fluoxetine ingestion throughout her pregnancy. Because this is the first reported case associating maternal Fluoxetine intake with fetal craniofacial malformations, a potential mechanism of injury is discussed.”

The baby boy born to nonconsanguinous parents “ had facial asymmetry with right microtia and mandibular hypoplasia; he also had bilateral hypoplastic macula, scoliotic deformity of the thoracic spine, and ventricular septal defect.”  That is, he had both craniofacial malformations and a heart defect.  Ventricular septal defect is a birth defect characterized by one or more small holes remaining open between the left and right ventricles after birth.  In turn, this inhibits proper oxygenation and cardiovascular performance, among other things.

Farra continues, noting that “The mother was under treatment with Fluoxetine 20 mg/day prior to conception and maintained the same dosage throughout her pregnancy” and states, “The occurrence of developmental aberrations may be caused by a profound serotonin receptor suppressive state in utero leading to aberrant clinical manifestations of the first and second branchial arches. Despite the very many limitations of case reporting of teratogenic events, it remains an important source of information on which more advanced research is based.”

Because so many expecting mothers have used Prozac unaware of the risks for serious congenital malformations, a number of Prozac® birth defects lawsuits have been filed.

If you or a loved one used Prozac and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Prozac® birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

Today, I found an article published in a 2013 edition of Pediatric Research by S.E. Haskell et al. (a team from University of Iowa Carver College of Medicine) titled “Sertraline exposure leads to small left heart syndrome in adult mice.” that further elucidates the connection between gestational Zoloft exposure and adverse birth outcomes.

Haskell writes, “Sertraline [(Zoloft)], a selective serotonin reuptake inhibitor (SSRI), is the most commonly prescribed therapy for maternal depression. Epidemiologic studies have linked SSRI exposure with decreased fetal growth, altered autonomic regulation, and cardiac malformations. We hypothesized that SSRI exposure decreases left-ventricular (LV) volumes and increases adult sympathetic nervous system activation, resulting in increased adult heart rates.” (emphasis added)

In non-scientific terms, the researchers were saying that studies looking back over groups that used Zoloft in pregnancy showed a link to birth defects, and that the present study’s hypothesis was that Zoloft exposure inhibits full development of the left ventricle of the heart.  This makes the heart work harder to circulate blood, resulting in a higher heart rate.

Results of this experiment showed that “Sertraline-exposed mice had smaller LV internal diameters in diastole (control 4.0 ± 0.1 mm, SSRI 3.7 ± 0.1 mm, P < 0.05), decreased stroke volumes (control 46 ± 2.6 µl, SSRI 37 ± 2.3 µl, P < 0.05), higher heart rates (control 530 ± 13 beats per minute (bpm), SSRI 567 ± 6 bpm, P <0.05), and increased urinary excretion of noradrenaline (control 174 ± 29.4 ng/ml, SSRI 276 ± 35.1 ng/ml, P < 0.05). These changes were associated with increased cerebral serotonin transporter (5-HTT) expression.”

As such, the team concluded that “Neonatal sertraline exposure causes long-term changes in cardiac morphology and physiology.” (emphasis added)

Because so many women have used Zoloft and other SSRIs during pregnancy unaware of the risk for heart defects, a number of Zoloft® birth defects lawsuits have been filed.  If you or a loved one used Zoloft and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Zoloft® birth defects lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.

A study published in the September, 2004 edition of The international journal of neuropsyhopharmacology titled “A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate.” by J. Rampono et al. provides further insight into the connection between gestational exposure to selective serotonin reuptake inhibitor drugs and adverse birth outcomes.  These drugs, such as Prozac, Paxil, Celexa, Effexor, Zoloft, and others, have been linked to a range of serious birth defects in the past two decades.

The authors write, “Antidepressants are often used antenatally, and placental transfer may lead to adverse effects (toxicity) in the neonate” and state that “Pregnant women taking fluoxetine (n=4), sertraline (n=4), paroxetine (n=2) or venlafaxine (n=1) in the last trimester were studied” in this trial, collecting “Maternal and cord sera … at delivery and infant serum on day 5 after birth for measurement of antidepressant concentrations. Neonatal Abstinence Scores (NAS) were measured in the infants on days 13 after birth.”

Results showed that “In maternal serum, median drug concentrations were: fluoxetine (96 microg/l), norfluoxetine (110 microg/l), sertraline (11 microg/l), desmethylsertraline (38 microg/l), paroxetine (mean 12 microg/l), venlafaxine (220 microg/l), and O-desmethylvenlafaxine (392 microg/l). Corresponding median values in cord serum were: fluoxetine (65 microg/l), norfluoxetine (81 microg/l), sertraline (10 microg/l), desmethylsertraline (27 microg/l), paroxetine (mean 6 microg/l), venlafaxine (232 microg/l), and O-desmethylvenlafaxine (406 microg/l). Corresponding median cord:maternal concentration ratios were 0.67 for fluoxetine and 0.72 for norfluoxetine, 0.67 for sertraline and 0.63 for demethylsertraline, 0.52 (mean) for paroxetine, and 1.1 and 1.0 for venlafaxine and O-desmethylvenlafaxine respectively.

This means that the antidepressant drugs studied all passed easily to the developing fetuses.  The team states, “The neonates of two patients taking fluoxetine had high NAS”, meaning that Prozac was linked to neonatal abstinence syndrome.

If you or a loved one used Prozac and gave birth to a child with a congenital malformation or who had perinatal complications, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Prozac® birth defect lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our SSRI Birth Defects Lawsuit Information page is a great place to start if you have any questions about SSRIs and Birth Defects.