April 2014

In early 2012, before the Propecia and Proscar Warning Labels were changed to include more information about sexaul side effects, a study published by Venkataram Mysore in Indian Dermatology Online Journal titled “Finasteride and sexual side effects” aimed to further clarify the relationship between finasteride (the active chemical in the the two aforementioned drugs) and long-term sexual side effects.

As such, the author states, “Finasteride, a 5-alpha reductase inhibitor, widely used in the medical management of male pattern hairloss, has been reported to cause sexual side effects. This article critically examines the evidence available and makes recommendations as to how a physician should counsel a patient while prescribing the drug.”

The author explains, “Pattern hair loss in males is androgenic in etiology. Antiandrogens such as finasteride are therefore useful in the management of the condition. Androgens, especially testosterone increases the libido. Any drug which interferes with the action of androgens is therefore assumed, by the lay person, to induce impotence.”

Continuing, it is noted “A number of studies have looked at the problem of side effects caused by finasteride.[6–11] These studies which are discussed below reveal that sexual adverse effects occur at the rates of 2.1% to 3.8%, erectile dysfunction (ED) being the commonest followed by ejaculatory dysfunction and loss of libido. These effects occurred early in the therapy and returned to normal on stopping or over a time on continuous use of the drug. The only causal relation between finasteride and sexual adverse effects is decreased ejaculatory volume because of predominant action of DHT on prostate.”

Due to the fact that a number of people have used Propecia and Proscar (Merck & Co., Inc.) without sufficient knowledge of the possibility of sexual side-effects, a number of Propecia lawsuits and Proscar lawsuits have been filed.  If you or a loved one used one of these drugs and suffered sexual side-effects, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Proscar lawyers and Propecia lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

A 2007 article by N. Mondaini et al. titled “Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon?” published in Journal of Sexual Medicine provides important insight into the connection between finasteride (the active chemical in the hair loss drug Propecia and the benign prostatic hyperplasia (BPH) drug Proscar) and long-term sexual side-effects.

The authors write “Sexual adverse experiences such as erectile dysfunction (ED), loss of libido, and ejaculation disorders have been consistent side effects of finasteride in a maximum percentage of 15% after 1 year of therapy.”

Studying 120 patients suffering from BPH who used finasteride for one year, half of whom were aware of sexual side effects and half of whom were not, the team found that “the incidence of ED, decreased libido, and ejaculation disorders were 9.6, 7.7, and 5.7% for group 1, and 30.9, 23.6, and 16.3% for group 2, respectively.”  While this study shows that the incidence of sexual side-effects may be impacted by patient expectation of those side-effects, the overall rate of adverse sexual side effects was high, and much higher than that reported in the Proscar warning label.

Due to the fact that many people have used finasteride unaware of the risk for adverse sexual side-effects, a number of Propecia lawsuits and Proscar lawsuits are currently being filed.  If you or a loved one used Propecia or Proscar and experienced adverse sexual side effects, you may be entitled to significant financial compensation for your injury.  For a free, no-obligation case consultation contact our team or Propecia lawyers and Proscar lawyers at the information provided below.  We have the compassion, experience, and resources required to win the justice you deserve.

Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

In 2003, an article published in International Journal of Impotence Research by D.J. Carbone Jr. et al. titled “Medical therapy for benign prostatic hyperplasia: sexual dysfunction and impact on quality of life.” aimed to clarify the link between use of finasteride, the active ingredient in hair loss drug Propecia and benign prostatic hyperplasia (BPH) drug Proscar, and long-term adverse sexual side-effects.

This study reviewed 73 previously-published reports on the subject, and found that “finasteride is associated with problems of ejaculation (2.1-7.7%), erection (4.9-15.8%), and libido (3.1-5.4%).”  The team writes, “Such significant and undesirable complications in relation to sexual function produce a well-documented negative impact on quality of life. Thus, optimal treatment for men with BPH requires the use of agents that demonstrate efficacy and safety with fewer sexual side effects.”

Due to the fact that Merck & Co., Inc., the manufacturer of Proscar and Propecia, has failed time and again to warn users of the risks associated with these drugs, a number of Proscar lawsuits and Propecia lawsuits have been filed: the warning labels for these drugs weren’t updated until April 2012, even though research demonstrating sexual side-effects had been published many years before.

If you or a loved one used finasteride in the form of Propecia or Proscar, please do not hesitate to contact our team of Propecia lawyers and Proscar lawyers at the information provided below, for you may be entitled to significant financial compensation.  We have the experience, resources, and compassion required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Recently, an article published in The American Journal of Cardiology titled “Risk of new-onset diabetes mellitus versus reduction in cardiovascular events with statin therapy.” provided important insight into the connection between statin drugs (Lipitor, Crestor, others) and new-onset diabetes.

KL Wang et al. (2014) write “The Food and Drug Administration recently updated the safety warning concerning the association between statin therapy and new-onset diabetes mellitus (NODM)” and “For prediabetes, little information is available for statins on cardiovascular outcome reduction and diabetogenic consequences.”  As such, “This study aimed to examine the risk of NODM and the reduction of cardiovascular events and death (MACE) after statin therapy in the prediabetic subjects.”

To establish a study cohort, this team used anonymous records from the Taiwan National Health Insurance agency and “A propensity score-matched model was constructed for statin users and nonusers.”  Overall, “Statin therapy was associated with a greater risk of NODM (hazard ratio 1.20, 95% confidence interval 1.08 to 1.32) and less risk of MACE (hazard ratio 0.70, 95% confidence interval 0.61 to 0.80), both in dose-dependent fashions.”

In non-scientific terms, this means that the rate of diabetes was increased by 20% among statin users, while the risk for cardiovascular events and death was lowered.  The latter part makes intuitive sense, for this is the overall aim of the drug.  While it is good that the drug performs its intended purpose, it is important that all users be aware of risks associated with any drug.  Unfortunately, the manufacturers of Lipitor, a very prominent statin drug, have failed to include adequate diabetes warnings on Lipitor packaging.

As a result, a number of Lipitor lawsuits have been filed.  If you or loved one used Lipitor and suffered diabetes as a result, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

An article appearing in the July, 2011 issue of Current Opinion in Cardiology titled “Are statins diabetogenic?” by U.K. Sampson et al. gives us a bit more information on the connection between drugs like Lipitor and new-onset diabetes.

The team writes “Statins are widely utilized for low-density lipoprotein lowering and for prevention of atherosclerotic cardiovascular disease. Although these drugs have a good safety record, increased risk of developing diabetes during extended use has recently garnered attention.”

A short article, this study evaluated the findings of the JUPITER study, a study that aimed to clarify the relationship between statins and diabetes, and “The JUPITER findings are supported by two recent meta-analyses of large-scale placebo-controlled and standard care-controlled trials, which, respectively, observed a 9% [odds ratio 1.09; 95% confidence interval (CI) 1.02-1.17] and 13% (risk ratio 1.13; 95% CI 1.03-1.23) increased risk for incident diabetes associated with statin therapy.”

(Statin drugs increase risk for diabetes 9-13%.)

The team continues “ the underlying mechanisms for this association remain unclear,” and concludes “The aggregate of large clinical trials supports the notion that statins modestly increase the risk of incident diabetes. Because diabetes is a risk equivalent condition for coronary and peripheral arterial diseases, these findings create a paradox whereby needed statin therapy may be withheld to avoid excess risk of diabetes while representing the strongest cardiovascular risk reduction tool in diabetics. We simply recommend regular glucose monitoring in patients taking statins.”

Due to the fact that Lipitor manufacturers and the manufacturers of other statin drugs have failed time and again to warn users of the risk for diabetes, a number of Lipitor lawsuits have been filed.  If you or a loved one used Lipitor and suffered diabetes, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

Published in the January, 2014 edition of the medical journal Liver Transplantation by Y. Cho et al., an article titled “Statin therapy is associated with the development of new-onset diabetes after transplantation in liver recipients with high fasting plasma glucose levels.”  provides further insight into the connection between statin therapy and new-onset diabetes.  For clarity, statin drugs are a class of cholesterol-lowering medications, and including Lipitor, Crestor, and others, are among the world’s most widely-prescribed.

Cho writes “it has recently been reported that statin therapy is associated with new-onset diabetes in the nontransplant population”, and thus “The aim of this study was to investigate the association between statin therapy and the development of NODAT in LT recipients.”

Studying 364 liver transplant patients without diabetic history, some of whom used statin drugs, the team found that the rate of diabetes after transplant was nearly double in the statin group: about 32% of statin users developed diabetes, while only 17.6% of non-statin patients developed diabetes.  The team also found that after adjusting for other risk factors, “Statin use was significantly associated with [new-onset diabetes after transplant]”, and importantly, confirms “There were no significant differences in age, body mass index, cumulative corticosteroid dose, or fasting plasma glucose (FPG) levels between the groups.”

Due to the fact that the manufacturers of statin drugs, particularly Lipitor, have failed time and again to warn users of the risk for diabetes associated with statin therapy, a number of Lipitor diabetes lawsuits have been filed.

If you or a loved one used Lipitor and suffered diabetes as a result, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

In 2014, an article published by Kwok Leung Ong et al. titled “Cardiovascular drugs that increase the risk of new-onset diabetes” in Curriculum in Cardiology aimed to further elucidate the connection between statin drugs and new-onset diabetes.  Statin drugs are a popular type of cholesterol-lowering medications including Lipitor, Crestor, Zocor, and many others.  Other classes of cholesterol-lowering medications include “niacin, thiazide diuretics, and ß-blockers,” all of which, including statins, have been found to increase the risk for developing diabetes by “9% to 43%”.

The team writes “The mechanisms whereby these drugs increase the risk of NOD are incompletely understood, although different hypotheses have been suggested. Lifestyle intervention consisting of diet and exercise has been shown in multiple studies to reduce the risk of NOD by approximately 50%, with persistent benefit during long-term follow-up. In patients at high risk for NOD, niacin should be avoided, and for hypertension, an angiotensin-converting enzyme inhibitor or even a ß1-selective blocker might be a better choice than a standard ß-blocker. For thiazide diuretics and particularly statins, benefit in terms of CV event reduction outweighs the risk of NOD.”

Unfortunately, the manufacturers of statin drugs (and others) have failed time and again to warn users of the increased risk for diabetes, regardless of the risk-benefit calculus pertaining to cardiovascular benefit associated with statin use.  As a result, a number of Lipitor diabetes lawsuits have been filed.

If you or a loved one used Lipitor or another cholesterol drug and suffered diabetes as a result, you may be entitled to significant financial compensation for your injury.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

Published in a 2011 edition of Atherosclerosis, a study titled “Differential metabolic effects of distinct statins.” by K.K. Koh et al. aimed to determine how statin drugs affect the body.  Statins are a class of cholesterol-lowering drugs including Lipitor, Crestor, Zocor, and others.

These researchers write “Reciprocal relationships between endothelial dysfunction and insulin resistance suggest that therapies improving endothelial dysfunction will simultaneously improve insulin sensitivity and other metabolic parameters. However, previous studies with some statins either did not alter insulin sensitivity or promoted insulin resistance despite significant improvements in endothelial dysfunction and decreases in circulating pro-inflammatory markers,” essentially implying that the scientific community had not clarified whether or not Lipitor and other statins raised the risk for diabetes.  Now, a number of studies link statin use to increased risk for diabetes, particularly in women.

This article continues, stating that “Clinical studies including large scale randomized controlled trials demonstrate potential differences between individual statins, with pravastatin promoting risk reduction for new onset of diabetes. Conversely, other statins including atorvastatin, rosuvastatin, and simvastatin all promote significant increase in this risk.”  This means that Pravachol has been found to decrease the risk for diabetes, while Lipitor, Crestor, and Zocor have been found to increase the risk for diabetes.

While the mechanism by which these drugs increase diabetes risk is as yet unclear, the risk is no less clear, and manufacturers of these drugs ought to warn users.  Because manufacturers have failed to do so, a number of statin-diabetes lawsuits have been filed, particularly Lipitor-diabetes lawsuits.  If you or a loved one used Lipitor or another statin and suffered diabetes, you too may be entitled to significant financial compensation.

For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

In 2010, a study was published in The New England Journal of Medicine titled “Adverse events associated with testosterone administration.” by S. Basaria and a team of researchers, aiming to further clarify adverse events associated with testosterone therapy.  Currently, testosterone therapy is provided in the treatment of “Low-T” and other ailments, many in the medical field believe that testosterone is overprescribed.  Further, studies have shown that testosterone is associated with an increased risk for cardiac arrest, stroke, and death, especially in older men.

Studying a group of men older than 65 with low testosterone, Basaria administered either a placebo topical “testosterone” gel or real testosterone topical gel such as Androgel to this cohort, and closely observed the group for six months.

At the end of the observation period, 209 men remained in the study.  The research team writes “During the course of the study, the testosterone group had higher rates of cardiac, respiratory, and dermatologic events than did the placebo group. A total of 23 subjects in the testosterone group, as compared with 5 in the placebo group, had cardiovascular-related adverse events”, findings consistent with the results of other studies on the association between adverse cardiac events and testosterone therapy, but from an admittedly small sample size.

As such, the team writes “In this population of older men with limitations in mobility and a high prevalence of chronic disease, the application of a testosterone gel was associated with an increased risk of cardiovascular adverse events. The small size of the trial and the unique population prevent broader inferences from being made about the safety of testosterone therapy.”

However, the manufacturers of AndroGel (AbbVie, Inc., Abbott Laboratories, Inc.), a popular topical testosterone gel, have failed time and again to warn users of this risk.  As a result, a number of AndroGel testosterone lawsuits are currently being filed.  If you or a loved one used AndroGel and suffered an adverse cardiac event, stroke, or death as a result, you may be entitled to significant financial compensation.

For a free, no-obligation case consultation, contact our team of AndroGel lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our AndroGel Lawsuit Information page is a great place to start if you have any questions about AndroGel.

In the April, 2013 edition of BMC Medicine, L. Xu et al. published the results of a study titled “Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials.”.  This study sought to assess the relative safety of testosterone therapy with respect to adverse cardiac events.  The research team writes “Testosterone therapy is increasingly promoted” and notes “No randomized placebo-controlled trial has been implemented to assess the effect of testosterone therapy on cardiovascular events, although very high levels of androgens are thought to promote cardiovascular disease.”

To perform this meta-analysis, Xu et al. (2013) reviewed previously-published randomized controlled studies involving testosterone administration and used statistics to normalize the results.  “Of 1,882 studies identified 27 trials were eligible including 2,994, mainly older, men who experienced 180 cardiovascular-related events.”  Overall, results showed that “Testosterone therapy increased the risk of a cardiovascular-related event” by 54%.

Importantly, this study also revealed that “In trials not funded by the pharmaceutical industry the risk of a cardiovascular-related event on testosterone therapy was greater (OR 2.06, 95% CI 1.34 to 3.17) than in pharmaceutical industry funded trials (OR 0.89, 95% CI 0.50 to 1.60).”

This means that studies funded by the pharmaceutical industry found testosterone therapy to have no connection with adverse cardiac events, while independent studies found testosterone therapy more than doubles the risk for adverse cardiac events.

Due to the fact that the manufacturers of testosterone therapy products such as AndroGel, a popular topical testosterone gel, have failed time and again to warn users of the risk for cardiac arrest, stroke, and death associated with AndroGel, a number of AndroGel lawsuits have been filed.  If you or a loved one used AndroGel and suffered one of these side effects, you may be entitled to significant financial compensation for your injury.  For a free, no-obligation case consultation, contact our team of AndroGel lawyers at the information provided below.  We have the experience, resources, and skills required to win the compensation you deserve.

Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our AndroGel Lawsuit Information page is a great place to start if you have any questions about AndroGel.