March 2014

A 2012 article by Dr. Ravi V. Shah and Dr. Allison B. Goldfine titled “Statins and Risk of New-Onset Diabetes Mellitus” published in Circulation, a journal of the American Heart Association, provides important insight into the connection between statin use and new onset diabetes.

The team writes “For any prescription drug, the potential benefits to health must be balanced against potential risks. Understanding these potential risks can help physicians and patients make informed decisions on whether to use a medication. Recently, statins, a class of medications prescribed to treat high cholesterol levels, have been found to modestly increase the risk of developing diabetes mellitus. It is clear that statins can prevent future major cardiovascular events, such as heart attack, stroke, and deaths from cardiovascular causes, in patients who have had a previous heart attack or those with multiple cardiovascular risk factors. However, the associations between diabetes mellitus and statin use have raised concerns over the widespread use of statin medications in patients at lower risk for cardiovascular disease”

Here is another excerpt: “Although patients on statins do have a higher risk of developing diabetes mellitus during the studies, they also experience a significant drop in cardiovascular events. In 1 study, diabetes mellitus was diagnosed in 27% more patients receiving a statin (rosuvastatin) compared with patients receiving placebo (an identical appearing pill that does not contain medication), but patients receiving the statin had a significant 54% lower risk of heart attack, 48% lower risk of stroke, and 20% lower risk of death from any cause.3

Click here to read the full article on statins and diabetes

Because the manufacturer or Lipitor has failed time and again to notify users of the risk for diabetes, a number of Lipitor diabetes lawsuits have been filed.  If you or a loved one used Lipitor and suffered diabetes as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Published in the May 2013 edition of Diabetes Care, an article by G Danaei et al. titled “Statins and risk of diabetes: an analysis of electronic medical records to evaluate possible bias due to differential survival.” aimed to determine if there was a bias in studies linking diabetes and statin drug use.  Statins are drugs that work to lower cholesterol including Lipitor, Crestor, Zocor, and others.

The team writes “We used electronic medical records from 500 general practices in the U.K. and included data from 285,864 men and women aged 50-84 years from January 2000 to December 2010. We emulated the design and analysis of a hypothetical randomized trial of statins, estimated the observational analog of the intention-to-treat effect, and adjusted for differential survival bias using inverse-probability weighting.”

Results showed that “During 1.2 million person-years of follow-up, there were 13,455 cases of type 2 diabetes and 8,932 deaths. Statin initiation was associated with increased risk of type 2 diabetes. The hazard ratio (95% CI) of diabetes was 1.45 (1.39-1.50) before adjusting for potential confounders and 1.14 (1.10-1.19) after adjustment. Adjusting for differential survival did not change the estimates. Initiating atorvastatin and simvastatin was associated with increased risk of type 2 diabetes.”

This means that the risk for diabetes was raised by between 14 and 45%.  For clarity, “atorvastatin” is the chemical name for Lipitor, a drug found linked to an increased risk for diabetes.  After statistical analyses, the team concluded that “In this sample of the general population, statin therapy was associated with 14% increased risk of type 2 diabetes. Differential survival did not explain this increased risk”, meaning that a bias was not found and that statin drugs do, in fact, raise the risk for diabetes.

Due to the fact that many people have used Lipitor and other statins unaware of the risk for diabetes, a number of Lipitor diabetes lawsuits have been filed.  If your or a loved one used Lipitor and suffered diabetes, you too may be entitled to significant financial compensation from the manufacturer.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

A 2013 article titled “Meta-analysis of impact of different types and doses of statins on new-onset diabetes mellitus.” published in The American Journal of Cardiology aimed to clarify the relationship between statin drug use and new onset diabetes by analyzing a number of previously conducted studies.  Statin drugs are cholesterol-lowering medications including Lipitor, Crestor, Zocor, and a number of others.

This team, led by EP Navarese, states “Recent reports indicate that statins are associated with an increased risk for new-onset diabetes mellitus (DM) compared with placebo and that this relation is dose dependent. The aim of this study was to perform a comprehensive network meta-analysis of randomized controlled trials (RCTs) investigating the impact of different types and doses of statins on new-onset DM.”

Reviewing a total of 17 randomized controlled trials including 113,394 patients revealed that “pravastatin 40 mg/day was associated with the lowest risk for new-onset DM compared with placebo (odds ratio 1.07, 95% credible interval 0.86 to 1.30)” and “Conversely, rosuvastatin 20 mg/day was numerically associated with 25% increased risk for DM compared with placebo (odds ratio 1.25, 95% credible interval 0.82 to 1.90). The impact on DM appeared to be intermediate with atorvastatin 80 mg/day compared with placebo (odds ratio 1.15, 95% credible interval 0.90 to 1.50).”

For clarity, atorvastatin is the active chemical in Lipitor, and these results indicate that Lipitor use raises the risk for diabetes by 15%.

Due to the fact that the manufacturers of Lipitor and other statin drugs have failed time and again to adequately warn users of the risk for diabetes, a number of Lipitor diabetes lawsuits have been filed.  If you or a loved one used Lipitor and suffered diabetes as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

An article published in the March 2014 edition of Current Radiology Reports by CN Bang et al. titled “Statin treatment, new-onset diabetes, and other adverse effects: a systematic review.” cites research linking statin use and new onset diabetes.  Statins are commonly-used cholesterol-lowering drugs including Lipitor, Zocor, Crestor, and many others.

Bang et al. (2014) state “The majority of the literature suggests an increased risk of new-onset diabetes in patients treated with statins in a number of different settings and that the risk appears greatest among the more potent statins.”  For clarity, Lipitor (atorvastatin) and Crestor (rosuvastatin) are commonly held as the most potent statin drugs available.

In addition to the risk of new onset diabetes associated with statins, this research team notes that “other side effects have been reported such as increased risk of myotoxicity, increased liver enzymes, cataracts, mood disorders, dementias, hemorrhagic stroke and peripheral neuropathy, which should maybe be added to the increased risk of new-onset diabetes, when considering the risk- benefit ratio of statin treatment.”

Due to the fact that many people have used Lipitor unaware of the risk for diabetes, a number of Lipitor diabetes lawsuits have been filed.  If you or a loved one used Lipitor and received a diabetes diagnosis, you may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

On  February 28th, 2012 the FDA issued a safety announcement alerting the public that Lipitor and other cholesterol-lowering statin drugs are associated with an increased risk for diabetes.

Click Here for an Infographic on How Statins Work

At that time, the FDA required safety label updates for statin drugs including warnings against “cognitive side effects (memory loss, confusion, etc.) and reports of increased blood sugar and glycosylated hemoglobin (HbA1c) levels”.  While the FDA believed that the cardiovascular benefit of using statins outweighed the risk for these side effects, the Administration thought it best that the public be aware of all known risks of using these drugs.

The FDA continues, citing a study that found a 27% increased risk for diabetes among statin users, and two other studies that reported a 9% and 13% increased risk.  As such, the FDA writes “Based on clinical trial meta-analyses and epidemiological data from the published literature, information concerning an effect of statins on incident diabetes and increases in HbA1c and/or fasting plasma glucose was added to statin labels.”

Sadly, the manufacturers of these drugs failed time and again to notify users of the risk for diabetes on their own, and as a result, a number of Lipitor diabetes lawsuits are currently being filed.  If you or a loved one used Lipitor or another statin drug and suffered diabetes as a result, you too may be entitled to significant financial compensation.

For a free, no-obligation case consultation, contact our team of Lipitor diabetes lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

In 2013, an article titled “Statins and risk of treated incident diabetes in a primary care population.” appearing in British Journal of Clinical Pharmacology aimed to determine whether or not statin use raises the risk for new onset diabetes.  Statin drugs include Lipitor, Crestor, and others and are prescribed to lower low-density cholesterol.  Researchers also set out to determine if higher doses or longer durations of use created more risk for diabetes.

For data, this team of researchers collected data from a national pharmaceutical records agency in Ireland and identified 239,628 patients who used statin drugs between January 1st, 2002, and December 31st 2007.  Of those patients, researchers found that 38,503 patients began using diabetes medication during that period, indicating that 38,503 cases of diabetes began while using statin medications.

After a series of statistical analyses, this team found that “Statin use was associated with an increased risk of new onset treated diabetes,” raising the risk for diabetes by 18% over non-users.  Not all statin drugs were found to raise the risk for diabetes equally, and Lipitor was found to raise the risk by 23%.  Researchers also found “There were statistically significant overall dose and duration effects for all statins, excepting fluvastatin, which only demonstrated a duration effect.”

Concluding that “An increased risk of new onset treated diabetes was found in those treated with statins showing significant duration and dose effect,” and due to the fact that Lipitor manufacturers fail to adequately warn for an increased risk for diabetes, this paper can be used as evidence in a Lipitor lawsuit to indicate that manufacturers knew, but failed to act.

If you or a loved one used Lipitor and suffered diabetes, you too may be entitled to significant financial compensation for your injuries.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

One article appearing in the August, 2013 edition of PLoS One by CW Chen et al. titled “Differential impact of statin on new-onset diabetes in different age groups: a population-based case-control study in women from an asian country.” aimed “to determine what effect, if any, statins have on the risk of [new onset diabetes (NOD)] events in a population-based case-control study. An evaluation of the relationship between age and statin-exposure on NOD risks was further examined in a female Asian population.”

To that effect, the Chen et al (2013) team studied 1065 female new onset diabetes patients and compared their health records with “10650 controls with matching ages, genders and physician visit dates.”

Results showed that “Statin-exposure was statistically significantly associated with increased new-onset diabetes risks using multivariate analysis” and “Interaction effect between age and statin-exposure on NOD risk was noted.”

Of all statin drugs tested, Lipitor was found to pose the highest risk for diabetes.  Researchers note “This population-based study found that statin use is associated with an increased risk of NOD in women. The risk of statin-related NOD was more evident for women aged 40-64 years compared to women aged 65 or more, and was cumulative-dose dependent. The use of statins should always be determined by weighing the clinical benefits and potential risks for NOD, and the patients should be continuously monitored for adverse effects.”

Due to the fact that the manufacturers of Lipitor have failed time and again to adequately warn users of the risks associated with their product, a number of Lipitor lawsuits have been filed.  If you or a loved one used Lipitor and suffered diabetes as a result, you too may be entitled to significant financial compensation for your undue injury.

For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

In 2012, a report published by KL Wang et al. in Journal of the American College of Cardiology titled “Statins, risk of diabetes, and implications on outcomes in the general population.” aimed to further clarify the relationship between statin drugs and new onset diabetes.  Statins are a class of cholesterol-lowering drugs including Lipitor, Crestor, and many others.  To-date, a number of studies have linked this class of medication with a dramatically increased risk for diabetes, particularly in women.

The team writes “Cardiovascular events as consequences of atherosclerosis and diabetes are reduced by statins. However, statins are associated with excessive risk of diabetes occurrence according to clinical trial analyses.”

Using data from the Taiwan National Health Insurance databases, Wang et al. (2012) identified subjects who used statin drugs for more than 30 days between 2000 and 2003, including only men older than 45 and women older than 55.  The team compared the rate at which these patients developed diabetes with four times as many people who had not used statins, matching them for “age, sex, atherosclerotic comorbidities, and year of their entry.”

Results showed that “Over a median of 7.2 years, annual rates of diabetes were significantly higher in statin users,” while the risks for heart attack and other adverse cardiac events in statin users were lower.

Due to the fact that the manufacturers of Lipitor and other statin drugs have failed time and again to warn users of the increased risk for diabetes associated with their products, a number of Lipitor lawsuits have been filed.  If you or a loved one used Lipitor and suffered diabetes as a result, you too may be entitled to significant financial compensation for your injuries.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the compassion, resources, and experience required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

Recently, I found a great page at the the FDA website outlining a variety of risks associated with Lipitor and other cholesterol-lowering statin drugs.

Here, the FDA cites diabetes, cognitive impairment, muscle damage, and liver injury associated with Lipitor and other similar drugs.

Unfortunately, the manufacturers of these drugs have failed time and again to adequately warn users of these risks (unless required outright by the FDA), and as a result a number of Lipitor diabetes lawsuits have ensued.

If you used Lipitor and suffered diabetes or another unadvertised side effect, you may be entitled to significant financial compensation for your injuries.  For a free no-obligation consultation, contact our team of Lipitor lawyers at the information provided below.  We have the experience, resources, and skills required to win the justice you deserve.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.

A 2012 paper by PM Ridker et. al published in The Lancet titled “Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial.” lives up to its title and outlines the cardiovascular benefits of using statin drugs (including Lipitor, Zocor, Crestor, and others) along with the risk for for diabetes associated with the use of these drugs: “In view of evidence that statin therapy increases risk of diabetes, the balance of benefit and risk of these drugs in primary prevention has become controversial.”

In this paper, the Ridker team evaluated results from the JUPITER trial, a large study that had found an increased risk for diabetes among statin users.  The Ridker team found that “for those with diabetes risk factors, a total of 134 vascular events or deaths were avoided for every 54 new cases of diabetes diagnosed.”

This study concluded that the cardiovascular benefit of using statin drugs outweighed the risk for diabetes.  That very well may be the case, and in fact is a positive thing.  The problem is that the manufacturers of Lipitor and other statin drugs failed time and again to notify users that there was an increased risk for diabetes associated at all.  While the benefits may outweigh the risks, it is essential that users make fully informed healthcare decisions.

As a result of this failure to warn, a number of Lipitor lawsuits have been filed.  If you or a loved one used Lipitor and suffered diabetes as a result, you too may be entitled to significant financial compensation.  For a free, no-obligation case consultation, contact our team of Lipitor lawyers at the information provided below.  We have the compassion, experience, and resources required to win the justice you deserve.  Call today and see how we can help.

(855) 452 – 5529

justinian@dangerousdrugs.us

Our Lipitor Lawsuit Information page is a great place to start if you have any questions about Lipitor.