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Dangerous Drugs & Medical Devices News & Commentary on Prescription Drug & Medical Device Lawsuits

Monthly Archives: December 2013

2013 – DePuy ASR hips linked to high blood metal ion levels

Posted in DePuy Hip Replacement

A 2013 article published in Hip International titled “Blood levels of cobalt and chromium are inversely correlated to head size after metal-on-metal resurfacing arthroplasty.” by a team of researchers led by MC Parry from the UK aimed to “assess the effect of head size, implant design and component positioning on metal production by resurfacing arthroplasties.”… Continue Reading

2013 – Study shows DePuy ASR failure rate 14.9% at 5 years

Posted in DePuy Hip Replacement

In a paper titled “Hip arthroplasty with the articular surface replacement (ASR) system: survivorship analysis and functional outcomes.” published in European Journal of Orthopaedic Surgery and Traumatology, the authors begin by stating “The articular surface replacement (ASR) hip resurfacing system, now withdrawn, has the highest all-cause revision rate (24.2 % at 7 years) compared with… Continue Reading

2013: Journal of Bone and Joint Surgery Connects High Blood Metal Ion Levels to DePuy ASR Hip Replacement Systems

Posted in DePuy Hip Replacement

A 2013 article published in The Journal of Bone and Joint Surgery titled “Relationship of Plasma Metal Ions and Clinical and Imaging Findings in Patients with ASR XL Metal-on-Metal Total Hip Replacements.” evaluated the health outcomes of 156 consecutive ASR total hip replacement patients in a particular clinic and studied the plasma metal ion levels… Continue Reading

2013 – Study Shows: ASR Hip Replacements Cause High Blood Metal Ion Levels

Posted in DePuy Hip Replacement

A 2013 article titled “Clinical and radiographic outcomes of 139 hips with articular surface replacement total hip arthroplasty*.” published in The Israel Medical Association Journal by A. Kadar et al. examined 139 uses of the Articular Surface Replacement (ASR; DePuy Orthopaedics Inc.) in a particular clinic and evaluated health outcomes and implant vitality. Kadar et… Continue Reading

2011 – Australian Joint Registry Finds 10% Revision Rate for DePuy ASR

Posted in DePuy Hip Replacement

In 2011, a report published in The Journal of Bone and Joint Surgery by RN de Steiger et al. “summarizes an analysis by the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) of the outcome of arthroplasties involving the ASR prostheses.” The Articular Surface Replacement (ASR) “metal-on-metal” hip implant by DePuy Orthopaedics, Inc. was recalled… Continue Reading

UK Government Agency Issues Alert for Complications with Metal-on-Metal Hips

Posted in DePuy Hip Replacement

A 2010 Medical Device Alert by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) – the equivalent of the FDA in the United States, made the following announcement regarding the safety of metal-on-metal (MoM) hip replacement systems. “The majority of patients implanted with MoM hip replacements have well functioning hips and are thought to be… Continue Reading

Allergan LAP-BAND fails at exceedingly-high rate

Posted in Allergan LAP-BAND

We are no longer accepting cases regarding these products.  Due to a terrible Supreme Court ruling, consumers injured by this product are no longer permitted to sue the manufacturers of this device.  We wish we could help, but the Supreme Court has taken the rights of citizens away to protect the profits of medical device… Continue Reading

Some metal-on-metal hips release fewer metal ions into the blood

Posted in DePuy Hip Replacement

A presentation at the 2010 annual meeting of the American Academy of Orthopaedic Surgeons titled “Clinical Follow-up and Metal Ions in Blood of Patients with Hip Resurfacing” demonstrated how different metal-on-metal hip replacements are associated with different levels of metal ions in the blood, a potentially-dangerous complication frequently observed in metal-on-metal hip replacement patients. This… Continue Reading

ProPublica: Lack of Government Oversight, Coordination Puts Medicare Patients at Risk

Posted in Politics, Public Health

One recent article by ProPublica, a prominent investigative journalism outlet, chronicles a lack of proper government oversight and coordination that “can expose Medicare recipients to potentially unsafe medical treatment and keeps tax dollars flowing to unworthy providers”. The problem is this: some doctors who are terminated from Medicaid practice due to “inappropriate drug choices [that]… Continue Reading

Research Finds Flu Vaccines More Effective in Women

Posted in Public Health

According to a recent study, flu vaccines may be more effective in women than in men. MedlinePlus, an online medical encyclopedia curated by the US National Institutes of Health and the National Library of Medicine made the following report: “Researchers measured immune responses in 53 women and 34 men after they received their seasonal flu… Continue Reading

2012 – Researchers Link Risperdal and Male Breast Growth

Posted in Risperdal

In a 2012 article titled “Prolactin, hyperprolactinaemia and antipsychotic treatment: a review and lessons for treatment of early psychosis.,” medical researchers J Cookson, R Hodgson, and HJ Wildgust explored the association between hyperprolactinemia and antipsychotic use. Hyperprolactinemia is an ailment characterized by increased blood levels of the hormone prolactin, which is responsible for breast growth… Continue Reading

2011 – Hyperprolactinemia associated with Risperdal, other antipsychotics

Posted in Risperdal

A 2011 article by MM Carvalho and C Góis, titled “Hyperprolactinemia in mentally ill patients” aimed to elucidate connections between antipsychotic drug use and hyperprolactinemia, an ailment characterized by increased blood prolactin levels that results in male breast development (gynecomastia). At the outset of their abstract, the authors make the sad recognition that “Hyperprolactinemia is… Continue Reading

2012 – Risperdal “probably” associated with gynecomastia

Posted in Risperdal

In 2012, a study titled “Drug-induced gynecomastia: an evidence-based review.” was published that aimed to clarify which drugs cause gynecomastia, the development of breasts in men. “Drugs are estimated to cause about 10 – 25% of all cases of gynecomastia. Over the course of several decades, multiple medications have been implicated in the development of… Continue Reading

2012 – Risperdal Causes Male Breast Enlargement in 43% of Boys

Posted in Risperdal

A number of recently-published studies have drawn the connection between use of the antipsychotic Risperdal and gynecomastia, male breast development.  One study researching this connection was published in The Journal of Child and Adolescent Psychopharmacology in 2012, and was titled “Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism… Continue Reading

2006 – Risperdal Results in Male Breast Development in at least 3 of 8 Patients

Posted in Risperdal

In recent years, a number of scientific studies have been published linking the antipsychotic drug Risperdal (risperidone) with gynecomastia – the development of breasts men.  An article published in a 2006 edition of The Journal of Clinical Psychopharmacology titled “Risperidone-induced symptomatic hyperprolactinaemia in adolescents.” by L. Holzer et al. addresses this risk.  For clarity, hyperprolactinemia… Continue Reading

Risperdal Warning Label Understates Gynecomastia Risk

Posted in Risperdal

According to an article published in a 2013 edition of the French medical journal L’Encephale, risperidone (Risperdal), an antipsychotic medication manufactured by Janssen Pharmaceuticals, Inc., is associated with gynecomastia — breast development in men. Risperdal and similar antipsychotics are considered “prolactin-raising” drugs, as they tend to result in elevated blood levels of prolactin, the hormone… Continue Reading

2010 – Certain Acetabular Angles Produce Less Pseudotumors in Metal-on-Metal Hip Implants

Posted in DePuy Hip Replacement

One doctor at the 2010 annual meeting of the American Academy of Orthopaedic Surgeons presented findings in a report titled “The role of acetabular component positioning in the development of Inflammatory Pseudotumors“. This surgeon, one George A. Grammatopoulos, MRCS notes that “acetabular component orientation is known to influence wear of metal-on-metal hip replacement bearings” and… Continue Reading

2010 – American Academy of Orthopaedic Surgeons Concerned about Metal-on-Metal Hip Implants

Posted in DePuy Hip Replacement

Notes from the 2010 annual meeting of the American Academy of Orthopaedic Surgeons demonstrate concern over the fact that metal ions can be released into the bloodstreams of metal-on-metal hip replacement patients, and state that the “Size, design, and position of resurfacing cups are critical factors leading to metal ion release,” but warn that “Definitive… Continue Reading

DePuy Pinnacle Hip Solution Guide Fails to Illustrate Risks

Posted in DePuy Hip Replacement

The DePuy Pinnacle Hip Solution Guide provides a great deal of information on different hip replacement systems offered by DePuy Orthopaedics.  As stated by the company, the Pinnacle Hip Replacement system “is designed with a wide range of acetabular cup options, biological and mechanical fixation alternatives and advanced bearing technologies. With more options than any… Continue Reading

2010 – Scientists study how metal ions wear off metal-on-metal hip replacements

Posted in DePuy Hip Replacement

Hip reconstruction procedures have been conducted for quite some time to treat severe hip arthritis, and there is more than one procedure when reconstructing the hip.  A total hip replacement involves removal of the femoral head, whereas a hip resurfacing is simply placing a mushroom shaped cap on top of the femur.  For many years,… Continue Reading