July 2013

Depacon (vallproic acid) is an antiepileptic drug used to treat a wide range of seizure disorders.  There are many benefits that patients receive from certain antiepileptic drugs.  However these drugs (AEDs) don’t go without certain side effects.  Some common side effects from AEDs are migraine headaches, dizziness, nausea, vomiting, sleepiness, weakness, change in taste, numbness or tingling of the skin, and psychiatric disorders.  The risks that are involved with older, more tested AEDs are known.  The same cannot be said about the new generation of AEDs.  The medical world does not have enough information to accurately speculate on what potential risks are associated with the new drugs.

One concern that is associated with antiepileptic drugs is their ability to interfere with the development of an embryo fetus that can lead to birth defects or developmental malformations. In the August issue of Neurology, (2006) Author Kimford J. Meador, MD and colleagues claim that the effect of Depakote had to do with the amount prescribed.

Furthermore, congenital malformations and fetal deaths were more common in pregnancies of women taking Depacon.  AED therapy is an important part to a successful pregnancy for women with epilepsy.  The AED therapy helps control and minimize the patients seizures during pregnancy.

Due to the facts that 1) many studies have shown that AED therapy is connected with major congenital malformations, and that 2) that the manufacturer of Depacon failed time and again to warn its customers of the risk for birth defects associated with Depacon, a number of Depacon lawsuits are currently being filed.

If you or a loved one used Depacon during pregnancy and your child was born with a birth defect, you may be entitled to significant financial compensation.  For more information on Depacon or a free, no-obligation Depacon case consultation, please feel free to call or e-mail our offices at the information provided below.

(855) 452-5529

justinian@dangerousdrugs.us

Call today and see how we can help!

Our Depacon Lawsuit Information page is a great place to start if you have any questions about the association between Depacon and birth defects.

Urinary incontinence plagues people all over the world, leading to experiences of discomfort and stress.  Midurethral mesh slings are now the most popular method for surgically alleviating urinary incontinence.  These mesh slings are the very same synthetic meshes that are used in pelvic floor reconstruction following pelvic organ prolapse.  In recent years, the difference between the efficacy and safety of synthetic mesh kits has been realized in respect to the surgeries mesh kits are used for.

A recent journal article found in Clinical Obstetrics and Gynecology, entitled, “Indications, Contraindications, and Complications of Mesh in the Surgical Treatment of Urinary Incontinence,” focused on the efficacy and safety of mesh kits used for the treatment of urinary incontinence.  Anna Kirby and Charles Nager reported in the article that, “Unlike transvaginal mesh for prolapse, complications related to mesh midurethral slings are low and less than the complication rates with previous traditional continence surgeries.  Given their safety profile and efficacy, full-length mesh midurethral slings have been rapidly adopted and remain the current standard of care for stress urinary incontinence surgical treatment.”  In other words, their report summarizes a problem that has currently given rise to a number of complications involving synthetic meshes: the safety and efficacy of synthetic mesh in surgical treatment for urinary incontinence has helped the swing of momentum for the use of synthetic mesh in the surgical treatment of prolapsed pelvic organs.

Given the research involving synthetic mesh for the treatment of urinary incontinence, medical professionals are more likely inclined to use synthetic mesh kits in the treatment of other ailments, namely of pelvic organ prolapse.  However, numerous transvaginal mesh lawsuits have arisen because of the lack of clinical research done confirming the safety and efficacy of synthetic mesh products.

The fact remains that while synthetic mesh has proven to be a safe and fairly effective product for the surgical treatment of urinary incontinence, the use of synthetic mesh in the treatment of prolapsed pelvic organs is considered to be unsafe and not entirely effective.  If you have experienced the adverse effects of synthetic mesh following pelvic organ prolapse surgery, then you may be the victim of a dangerous product not yet proven to be safe for patient use.  Please contact our law offices to complete a free, no-obligation case consultation to determine if you are eligible for a transvaginal mesh lawsuit.

At your convenience, you may reach our offices by phone at (855) 452-5529 or by e-mail at justinian@dangerousdrugs.us.

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about Transvaginal Mesh

Because nearly one tenth of all women worldwide experience pelvic organ prolapse (POP) during their lives, many top medical professionals today strive to develop treatment more reliable than transvaginal mesh (TVM), a treatment option associated with a high rate of failure and complications of vaginal mesh.

A current study titled, “Indications, Contraindications, and Complications of Mesh in Surgical Treatment of Pelvic Organ Prolapse,” turned its focus towards the alarming increase in patients who require a second surgical repair because of a recurrence of POP after TVM use.  David Ellington and his partner Holly Richter in their 2013 Clinical Obstetrics and Gynecology article studied the potential benefits and risks of using transvaginal mesh kits to try to lower the risk of reoccurrence of the original symptoms in patients.  They determined that while clinical research is starting to become more important in the eyes of federal regulators, the situation still lies where, “physicians need to continue to review the literature, report their own outcomes, and educate patients regarding new outcome date, complications, and recommendations, from national organizations in women’s health regarding prolapse repair.”

While this summary is encouraging as it indicates that efforts are starting to be made towards informing patients as thoroughly as possible of the risks associated with TVM, the fact still remains that numerous incidents have occurred involving the contraindications of transvaginal mesh kits, prompting a large number of transvaginal mesh lawsuits to be filed.  Many TVM lawsuits are filed because of the expensive and often times painful additional surgeries required to correct the complications caused by transvaginal mesh.

If you have required surgery to repair the damage caused by the use of transvaginal mesh, you may be eligible for a transvaginal mesh lawsuit and we encourage you to contact our offices to receive a free consultation.

At your convenience, you may reach our offices by phone at (855) 452-5529 or by e-mail at justinian@dangerousdrugs.us.  Call today and see how we can help!

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about Transvaginal Mesh

The use of transvaginal mesh kits in pelvic floor reconstruction surgery has begun to be questioned clinically as the number of cases of complications and adverse effects has steadily risen.  The  complications can lead to pain for not only the patient but for their significant others during intercourse, often times leading patients to require further corrective surgery.  Recently, a new complication has been reported by numerous patients, involving the erosion of the tissue surrounding synthetic mesh inside the patient’s body.

A recent study titled, “Diagnosis, Management and Prognosis of Vaginal Erosion after Transobturator Suburethral Tape Procedure Using a Nonwoven Thermally Bonded Polypropylene Mesh,” conducted by Domingo, et. al., focused efforts on understanding the possible outcomes of the erosion of the vagina following transvaginal mesh within patients.  The article, as seen in The Journal of Urology aimed at studying transvaginal mesh erosion in patients undergoing surgery to treat urinary incontinence in women.  They reported that, “of the 65 patients 9 (13.8%) were diagnosed with vaginal erosion at the vaginal incision during a relatively long postoperative period (mean 290 days). All presented with vaginal discharge and 1 had a severe complication (obturator abscess). Complete mesh removal was necessary in 8 patients and only 2 (22%) had recurrent stress urinary incontinence.”

Thers results confirm the current suspicions surrounding the use of transvaginal mesh in patients, as the study reports serious complications as well as failures that end in recurrent symptoms.  This study, along with others, has shown that numerous patients have become victims of the dangerous transvaginal mesh products currently in clinical use.

If you or a loved one has suffered from any complications following surgery involving transvaginal mesh kits, you may be eligible for a transvaginal mesh lawsuit.  Our lawyers want to offer you a free, no-obligations consultation to help you receive compensation for the suffering you have endured.

Contact us today either by phone at (855) 452-5529 or by e-mail at justinian@dangerousdrugs.us to see how we can help!

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about Transvaginal Mesh.

Currently, synthetic mesh kits are being more commonly used in reparatory surgery for prolapsed pelvic organs.  However, as stated by Lawrence Lin, et. al., in a recent article titled, “Dyspareunia and Chronic Pelvic Pain after Polypropylene Mesh Augmentation for Transvaginal Repair of Anterior Vaginal Wall Prolapse,” there seems to be no clinical research on the safety of such kits.  The researchers state, “There is a growing use of synthetic mesh placement in the vagina without sufficient evidence of clinical studies on patient safety for these procedures.”

Lin and his team focused on the fact that there is very little attention paid towards transvaginal mesh kits in their postoperative complications.  The study summarized the experience of a patient, whom after receiving a synthetic mesh kit for anterior prolapsed pelvic organ repair, suffered from extreme dyspareunia and debilitating pelvic pain.  The patient, after being surgically implanted with transvaginal mesh experienced pain and discomfort postoperatively, failed to have a positive response from medical therapy, eventually leading to further surgery to remove the mesh kit.

Cases similar to this patient’s have emerged in alarming numbers, with patients reporting similar complications and often times requiring further surgery to repair the damage caused by transvaginal mesh kits.  If you or a loved one has experienced any sort of complication following surgery involving transvaginal mesh kits, then it may be the result of the lack of clinical research done on that product’s safety and efficacy; you may be entitled to compensation for the suffering you have endured.

Contact me, Justinian Lane, at the information below and let me help you.  I have the experience, skills, and resources required to win the justice you deserve in a transvaginal mesh lawsuit.

For more information, please feel free to call or e-mail our team at the information provided below.

(855) 452-5529

justinian@dangerousdrugs.us

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about Transvaginal Mesh.

The use of transvaginal mesh kits has grown substantially in recent years as new products are being designed constantly.  However, numerous transvaginal mesh lawsuits have emerged because of the inconsistent success rates offered by the field of different transvaginal mesh products.  Lawsuits have not only emerged because of unsuccessful procedures involving transvaginal mesh kits, but because of the high number of complications that occur, often times leading patients into experiences of severe pain and discomfort.

In a recent study in Female Pelvic Medicine & Reconstructive Surgery, an article titled “Elevate Anterior/Apical: 12-month Data Showing Safety and Efficacy in Surgical Treatment of Pelvic Organ Prolapse,” focused on the possible repercussions of transvaginal mesh in reparatory surgery.  Edward Standford and his team focused on the possible outcomes of using transvaginal mesh kits in the surgical repair of prolapsed pelvic organs one year after surgery.  They listed a fairly high success rate but noted a range of complications that occurred in numerous subjects.  These complications included but were not limited to: “…mesh exposure, urinary tract infections, transient buttock pain, de novo stress incontinence, retention, dyspareunia, and hematoma,” each of which cause significant stress in patients’ lives.

Though transvaginal mesh kits have gained popularity in clinical use, they have brought with them a host of TVM complications, that when objectively studied, have shown to prove that transvaginal mesh kits are being seen as less and less of a viable and safe method for the repair of prolapsed pelvic organs.

If you have experienced any of the listed adverse effects of transvaginal mesh following reparatory surgery, then you may be one of the many victims of an unsafe and ineffective medical device, transvaginal mesh.  Contact our offices and let us provide you with the representation you need to win the justice you deserve for your suffering.

(855) 452-5529

justinian@dangerousdrugs.us

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about Transvaginal Mesh.

With the current controversy surrounding the use of transvaginal mesh kits for the reparatory surgery of prolapsed pelvic organs, alternatives methods are constantly being explored.  Recently, polypropylene slings have been used instead of more traditional transvaginal mesh kits using other synthetic bases for their designs, utilizing a tension-free sling that is aimed at causing fewer complications than previous products.  A recent study conducted by Katlheen Kobashi and Fred Govier aimed at examining the possible complications that could occur due to the use of polypropylene slings for the repair of prolapsed pelvic organs.

Their study reported that, “two patients described persistent vaginal discharge 6 weeks postoperatively, including 1 who complained primarily of partner discomfort during sexual intercourse. Two patients were completely asymptomatic and mesh erosion was discovered at routine physical examination 6 weeks postoperatively.  Pelvic examination demonstrated vaginal exposure of the mesh in all cases.”  These results indicate that while some complications are obvious as it causes discomfort and physiological symptoms easily identified by doctors during examination, some complications go unnoticed for a significant time before they are discovered.

According to this research, polypropylene slings have similar adverse effects to that of other tested methods for correcting prolapsed pelvic organs, resulting in minor to serious complications.  These complications can lead to unnecessary pain and discomfort for patients.

If you or a loved one used transvaginal mesh and experienced the side-effects described above, or another complication of transvaginal mesh, you may be entitled to significant financial compensation for your injuries through a transvaginal mesh lawsuit.

For a free, no-obligation case consultation, please do not hesitate to contact our team of transvaginal mesh lawyers (855) 452-5529 or by e-mail at justinian@dangerousdrugs.us.

We have the experience, resources, and skills required to win the justice you deserve.  Call today and see how we can help!

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about transvaginal mesh.

The use of transvaginal mesh in the surgical repair of pelvic organ prolapse has recently led to a large number of transvaginal mesh lawsuits as a result of the inconsistent success rates and the numerous complications associated with these methods.  The controversy has mainly stemmed from the lack of clinical research done to prove the safety of the constantly changing updated version of the transvaginal mesh kit products, produced by a host of companies worldwide.    However, a new concern has arisen for clinical scientists investigating the safety of transvaginal mesh kits: the effect of their use on the female sexual function.

A current study conducted by Chiu-Lin Wang, et. al. evaluated the short-term impact of surgical repair with total transvaginal mesh (TVM) on sexual function among women with pelvic organ prolapse.  After testing a range of patients with preoperative and postoperative questionnaires, Wang and colleagues determined that scores for dyspareunia and the lubrication domains of the female sexual function index were significantly lower following reparatory surgery involving transvaginal mesh.  The study reported that that two-thirds of TVM patients had a significantly lower female sexual function index scores postoperatively, indicating that the unwanted effects of transvaginal mesh were highly prevalent for patients.

Corrective surgery to fix prolapsed pelvic organ tissue is aimed at allowing patients to return to the physical normalcy, without pain and without discomfort.  The use of transvaginal mesh kits has been heavily questioned because of how little research has been done to prove their safety, but now research has started to indicate that these devices have been seen to cause further complications, now affecting the sexual functioning of patients.  If you have experienced any sort of postoperative discomfort, pain, or abnormalities following prolapsed pelvic organ surgery involving transvaginal mesh, then you may be the victim of a dangerous product, unfit for clinical use.

Contact our offices at the information provided below to set up your free, no-obligations consultation either by phone at (855) 452-5529 or by e-mail at justinian@dangerousdrugs.us.

Our Transvaginal Mesh Lawsuit Information page is a great place to start if you have any questions about Transvaginal Mesh.

In 2004, a study published in Epilepsy & Behavior demonstrated that the new generation of antiepileptic drugs (AEDs) pose less danger to a developing fetus than do older drugs.

This study comes from an Argentinian research team led by Meischenguiser et al. who studied two different groups of children: one group of children whose mothers used old-generation AEDs (phenobarbital, valproate, and carbamazepin), and one cohort of children born to mothers who used newer AEDs, such as oxcarbazepine.

Of the 114 children exposed to mothers who used older AEDs, 16 major congenital malformations were observed, “16 newborns had anomalies: 3 cardiac, 3 skull, and 2 gastrointestinal malformations, and 8 facial dysmorphies.”

Only one child out of 50 children exposed to oxcarbazepine was born with a major congenital malformation.  That child’s mother also, however, used old-generation AEDs during pregnancy, and thus it is impossible to tell whether the malformation observed was the result of the older or the newer medication that she used.

Regardless, this small study has effectively demonstrated that if you are epileptic and become pregnant, it may be safer to use newer AEDs rather than older ones.  Also, the United States FDA has warned against sodium valproate (Depacon) use during pregnancy.  Each year, more studies come out showing the danger associated with old generation AEDs, the most dangerous of which is consistently demonstrated to be sodium valproate (Depacon, Depakene, Depakote).

Depacon has been shown to dramatically raise the risk children face of being born with neurological, cardiovascular, craniofacial birth defects, and autism, but sadly, the manufacturer of this drug, Abbott Laboratories, has failed to make these risks clear to its users.

If you used Depacon unaware of the risks its use carries, and your child was born with a congenital malformation, you may be eligible to file a Depacon lawsuit, seeking compensation for the undue injury Deacon can cause.

For more information on Depacon or Depacon lawsuits, feel free to call or e-mail our team of Depacon lawyers at the phone number or e-mail address provided below.  We have the resources and experience to fight even the largest pharmaceutical companies and win the justice you deserve.

(855) 452-5529

justinian@dangerousdrugs.us

Our Depacon Lawsuit Information page is a great place to start if you have any questions about Depacon.

In 2007, a team of researchers led by U. Kini et al. set out to prove whether or not the genetics played a role in elevating the the observed risk for major congenital malformations in children exposed to antiepileptic drugs in utero.  That is, “Can an epileptic mother’s genes change the likelihood that her child will be born with birth defects, if she chooses to use antiepileptic drugs during pregnancy?  Do certain genes make already-dangerous drugs worse?”

The U. Kini et al. (2007) study sought to evaluate whether or not a certain polymorphism (abnormality) in the MTHFR gene, in addition to the presence of antiepileptic drugs, contributed to a negative developmental outlook.

The main antiepileptic drug studied was sodium valproate, because “sodium valproate (VPA) was the most commonly used drug and was associated with the highest rate of malformations (9.6%).”

Sodium valproate is the active ingredient in antiepileptic drugs, such as Depacon, Depakene, and Depakote.  Many studies have shown that maternal use of Depacon during pregnancy greatly raises the risk her children face for being born with one of a range of life-threatening birth defects of the heart, brain, and skull.

To put it simply, Kini’s research did not illuminate a significant connection between the MTHFR gene and birth defects.  His team concluded that although some children whose mothers used AEDs (particularly sodium valproate) and had this specific genetic defect, it is likely that harms caused by sodium valproate “are mediated through other mechanisms.”

Due to the fact that the manufacturer of Depacon, Abbott Laboratories, did not make the risks of Depacon use clear, a number of Depacon lawsuits have been filed around the country.  If you or a loved one used Depacon and your child was born with a birth defect, you may be entitled to significant financial compensation for undue injury to your family.

For more information on Depacon, please feel free to contact our team of Depacon lawyers by phone at (855) 452-5529 or by e-mail at justinian@dangerousdrugs.us.

Our Depacon Lawsuit Information page is a great place to start if you have any questions about Depacon.