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Category Archives: Risperdal

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1999 – Large study finds Risperdal linked to hormonal side effects including male breast growth

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Over the last decade or so, a number of articles have been published concerning the link between the use of the atypical antipsychotic drug Risperdal (risperidone) and elevated prolactin levels, ensuing gynecomastia.  (Prolactin is the hormone responsible for breast development and milk production.) Here, we will discuss one such article, published in a 1999 edition… Continue Reading

2003 – Elevated prolactin levels seen in 65% of Risperdal patients

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In 2003, the results of a small study titled “Risperidone-associated hyperprolactinemia: evaluation in twenty psychiatric outpatients.” by S. Brunelleschi were published in Psychopharmacological Research (the official journal of the Italian Pharmacological Society), aiming to elucidate a potential link between use of Risperdal (risperidone) and hyperprolactinemia (elevated prolactin levels).  For clarity, prolactin is the hormone responsible… Continue Reading

2010 – Risperdal raises prolactin in both male and female patients

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In 2010, a team of researchers led by N. Yasui-Furukori et al. published the results of a study titled “Gender-specific prolactin response to antipsychotic treatments with risperidone and olanzapine and its relationship to drug concentrations in patients with acutely exacerbated schizophrenia.” in Progress in Neuro-psychopharmacology & Biological Psychiatry that aimed to determine the extent of… Continue Reading

2005 – Study finds 92.3% of Risperdal patients suffer hyperprolactinemia

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In 2005, a team of Polish researchers published a study titled “Prolactin secretion disturbances in schizophrenic patients treated with 2nd generation antipsychotics–risperidone and olanzapine” in Psychiatria Polska that aimed to further elucidate the connection between the use of second-generation antipsychotics and elevation of prolactin.  Prolactin is a hormone in the body responsible for breast development… Continue Reading

2006 – 11 of 12 Risperdal patients suffered hyperprolactinemia

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A 2006 piece published in Neuroendocrinology Letters by M. Kopecek et al. titled “Low-dose risperidone augmentation of antidepressants or anxiolytics is associated with hyperprolactinemia.” states “Risperidone in antipsychotic doses induces hyperprolactinemia” and aims to “verify whether the same is true for low doses of risperidone (0.5-2 mg per day) added to antidepressants or anxiolytics.”  That… Continue Reading

2005 – Risperdal increases prolactin levels in children two-fold, adults eight-fold

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In 2005, a team of researchers led by JA Hellings published a report titled “Risperidone-induced prolactin elevation in a prospective study of children, adolescents, and adults with mental retardation and pervasive developmental disorders.” that aimed to determine if Risperdal (risperidone) caused elevated prolactin levels in females more than males.  Elevated prolactin levels (hyperprolactinemia) may result… Continue Reading

2005 – Elevated prolactin levels found in 68% of youth Risperdal users

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In 2005, a report by JR Stevens et al. published in Journal of Child and Adolescent Psychopharmacology and titled “Elevated prolactin levels in male youths treated with risperidone and quetiapine.” aimed to determine the extent to which Risperdal (risperidone) and Seroquel (quetiapine) raised levels of prolactin in patients.  Prolactin is the hormone responsible for breast… Continue Reading

2001 – Study shows Risperdal caused 28% of children to have elevated prolactin levels

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A 2001 paper by G. Masi et al. published in Journal of Child and Adolescent Pharmacology begins its abstract as follows: “Although hyperprolactinemia is a common side effect during risperidone treatment in adult patients, no information is available on young children.” To be clear, hyperprolactinemia is a condition characterized by elevated blood levels of prolactin,… Continue Reading

2005 – 89% of Risperdal users found to suffer elevated prolactin levels

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A paper published in 2005 by K. Melkersson in Journal of Clinical Psychiatry titled “Differences in prolactin elevation and related symptoms of atypical antipsychotics in schizophrenic patients.” aimed to evaluate the degree to which different atypical antipsychotic drugs elevated blood levels of prolactin (the hormone responsible for breast growth and milk production) in a group… Continue Reading

2005 – Risperdal raises prolactin levels more than Haldol

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In a 2005 report by XY Zhang et al. titled “Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol: a double-blind and randomized study.” published in Psychopharmacology, researchers aimed to “compare the effect of risperidone and haloperidol on serum PRL and investigate the relationship between serum PRL levels and clinical response in patients… Continue Reading

2009 – Risperdal shown to lower testosterone, raise prolactin – leading to male breast growth

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In 2009, a study on the effects two antipsychotic medications – risperidone (Risperdal) and olanzapine had on sex hormone levels was published in Psychoneuroendocrinology. For years, many studies have been published connecting Risperdal and elevated prolactin levels (the hormone responsible for breast growth and milk production), demonstrating that Risperdal may lead to gynecomastia – male… Continue Reading

2000 – Risperdal raises levels of hormone responsible for male breast growth more than other similar drugs

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According to an article published in the September 2000 edition of Clinical Therapeutics, risperidone (Risperdal) raised prolactin levels significantly more than two other common antipsychotic drugs tested, olanzapine and haloperidol. This is important because elevated prolactin levels can lead to gynecomastia – the development of breasts in males, a condition which can be very traumatizing,… Continue Reading

2003 – Study shows Risperdal causes more hyperprolactinemia than other antipsychotics

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A 2003 report by BJ Kinon et al. published in Psychoneuroendocrinology reports that risperidone (Risperdal) leads to elevated prolactin levels at a much greater rate than other antipsychotics. Hyperprolactinemia, a condition characterized by elevated levels of prolactin – the hormone responsible for breast growth and milk production, carries with it a number of negative side… Continue Reading

2004 – Study links Risperdal and Male Breast Growth

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In 2004, P.M. Haddad et al. published a report in the medical journal Drugs titled “Antipsychotic-induced hyperprolactinaemia: mechanisms, clinical features and management.”  Aiming to elucidate the biochemical mechanism by which certain antipsychotic medications cause hyperprolactinemia (elevated blood levels of prolactin, the hormone responsible for breast development and milk production), the abstract to the article begins… Continue Reading

2007 – Study Links Risperdal and Male Breast Growth

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A 2007 Journal of Clinical Psychopharmacology article titled “Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives.” provides valuable insight into complications and side-effects related to the use of certain “atypical” antipsychotic medications, specifically into those related to risperidone (Risperdal® – Janssen Pharmaceuticals, Inc.). One… Continue Reading

2009 – Hyperprolactinemia, male breast growth associated with Risperdal

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According to a 2009 study published in the medical journal Pharmacotherapy by JR Bostwick titled “Antipsychotic-induced hyperprolactinemia.”, “Use of antipsychotic agents has been associated with hyperprolactinemia, or elevated prolactin levels; this hormonal abnormality can interfere with the functioning of reproductive, endocrine, and metabolic systems” and “First-generation antipsychotics pose the greatest risk of causing [the] adverse… Continue Reading

2012 – Researchers Link Risperdal and Male Breast Growth

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In a 2012 article titled “Prolactin, hyperprolactinaemia and antipsychotic treatment: a review and lessons for treatment of early psychosis.,” medical researchers J Cookson, R Hodgson, and HJ Wildgust explored the association between hyperprolactinemia and antipsychotic use. Hyperprolactinemia is an ailment characterized by increased blood levels of the hormone prolactin, which is responsible for breast growth… Continue Reading

2011 – Hyperprolactinemia associated with Risperdal, other antipsychotics

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A 2011 article by MM Carvalho and C Góis, titled “Hyperprolactinemia in mentally ill patients” aimed to elucidate connections between antipsychotic drug use and hyperprolactinemia, an ailment characterized by increased blood prolactin levels that results in male breast development (gynecomastia). At the outset of their abstract, the authors make the sad recognition that “Hyperprolactinemia is… Continue Reading

2012 – Risperdal “probably” associated with gynecomastia

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In 2012, a study titled “Drug-induced gynecomastia: an evidence-based review.” was published that aimed to clarify which drugs cause gynecomastia, the development of breasts in men. “Drugs are estimated to cause about 10 – 25% of all cases of gynecomastia. Over the course of several decades, multiple medications have been implicated in the development of… Continue Reading

2012 – Risperdal Causes Male Breast Enlargement in 43% of Boys

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A number of recently-published studies have drawn the connection between use of the antipsychotic Risperdal and gynecomastia, male breast development.  One study researching this connection was published in The Journal of Child and Adolescent Psychopharmacology in 2012, and was titled “Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism… Continue Reading

2006 – Risperdal Results in Male Breast Development in at least 3 of 8 Patients

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In recent years, a number of scientific studies have been published linking the antipsychotic drug Risperdal (risperidone) with gynecomastia – the development of breasts men.  An article published in a 2006 edition of The Journal of Clinical Psychopharmacology titled “Risperidone-induced symptomatic hyperprolactinaemia in adolescents.” by L. Holzer et al. addresses this risk.  For clarity, hyperprolactinemia… Continue Reading

Risperdal Warning Label Understates Gynecomastia Risk

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According to an article published in a 2013 edition of the French medical journal L’Encephale, risperidone (Risperdal), an antipsychotic medication manufactured by Janssen Pharmaceuticals, Inc., is associated with gynecomastia — breast development in men. Risperdal and similar antipsychotics are considered “prolactin-raising” drugs, as they tend to result in elevated blood levels of prolactin, the hormone… Continue Reading