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Category Archives: DePuy Hip Replacement

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2011 – 32% of Metal-on-Metal Hip Replacement Patients Endure Pseudotumors

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A 2011 article by D.H. Williams et al. published in that year’s December edition of Journal of Bone and Joint Surgery (US) titled “Prevalence of pseudotumor in asymptomatic patients after metal-on-metal hip arthroplasty.” sheds further important insight into the tendency for metal-on-metal hip replacements to release dangerous metal ions into the bloodstream. One result of… Continue Reading

2012 – 40% of metal-on-metal hip replacement patients face adverse reaction to metal debris

Posted in DePuy Hip Replacement

A 2012 article by I.A. Malek et al. published in Journal of Bone and Joint Surgery titled “The sensitivity, specificity and predictive values of raised plasma metal ion levels in the diagnosis of adverse reaction to metal debris in symptomatic patients with a metal-on-metal arthroplasty of the hip.” helps demonstrate the rate at which patients… Continue Reading

2012 – Very high rate of pseudotumors seen with metal-on-metal hip replacements

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In a 2012 study appearing in Clinical Orthopaedics and Related Research titled “Pseudotumors are common in well-positioned low-wearing metal-on-metal hips.”, AK Matthies et al. write “Pseudotumors are sterile inflammatory lesions found in the soft tissues surrounding metal-on-metal (MOM) and metal-on-polyethylene hip arthroplasties. In patients with MOM hip arthroplasties, pseudotumors are thought to represent an adverse… Continue Reading

2010 – Pseudotumors, high metal ion levels associated with metal-on-metal hip replacements

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A 2010 article published in Journal of Orthopaedic Research by YM Kwon et al. titled “Lymphocyte proliferation responses in patients with pseudotumors following metal-on-metal hip resurfacing arthroplasty.” studied “the incidence and level of metal-induced systemic hypersensitivity in patients” who underwent metal-on-metal hip resurfacing arthroplasty (MoHRA), “both with and without pseudotumor by measuring lymphocyte proliferation responses… Continue Reading

2013 – Pseudotumors linked to metal-on-metal hip arthroplasty

Posted in DePuy Hip Replacement

In 2013, a paper published in Clinical Orthopaedics and Related Research titled “The natural history of inflammatory pseudotumors in asymptomatic patients after metal-on-metal hip arthroplasty.” by SA Almousa et al. provides background for itself, stating in part “Although pseudotumors have been reported in 32% of asymptomatic metal-on-metal hips, the natural history of asymptomatic pseudotumors is… Continue Reading

2013 – Many metal-on-metal hip replacement patients suffer adverse reactions to metal debris

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An article appearing in the May, 2013 edition of Orthopedics titled “Prevalence of adverse reactions to metal debris following metal-on-metal THA.” by M. Hasegawa et al. lives up to its title and aimed to “determine the prevalence of adverse reactions to metal debris (ARMD) following large-diameter metal-on-metal total hip arthroplasty.” In recent years, a number… Continue Reading

2008 – Study shows smaller metal-on-metal hip replacements cause smaller increase in blood metal ion levels

Posted in DePuy Hip Replacement

In a 2008 article published by J. Antoniou et al. in The Journal of Bone and Joint Surgery titled “Metal ion levels in the blood of patients after hip resurfacing: a comparison between twenty-eight and thirty-six-millimeter-head metal-on-metal prostheses.”, the authors write “Metal ion toxicity, metal hypersensitivity, and metal carcinogenicity are causes for concern for patients… Continue Reading

2011 – Metal ion levels “significantly higher” in metal-on-metal hip replacements at 24 months

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In a 2011 report by JM Smolders et al. published in Acta Orthopaedica titled “Metal ion levels and functional results after either resurfacing hip arthroplasty or conventional metal-on-metal hip arthroplasty.”, a team of medical researchers aimed to determine whether larger cup sizes in metal-on-metal hip replacements led to higher levels of metal ions in the… Continue Reading

2011 – Study Shows: 12% of DePuy ASR XL hip replacements fail by 2 years

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In 2011, a paper titled “Early failure of articular surface replacement XL total hip arthroplasty.” in The Journal of Arthroplasty by GD Steele et al., stated “The ASR (articular surface replacement) XL (DePuy, Warsaw, Ind) metal-on-metal hip arthroplasty offers the advantage of stability and increased motion. However, an alarming number of early failures prompted the… Continue Reading

“Out of joint: The story of the ASR” – British Medical Journal

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In 2011, Deborah Cohen, investigations editor for the British Medical Journal wrote a piece called “Out of joint: The story of the ASR,” which chronicles the ill-fated history of the DePuy ASR metal-on-metal hip replacement systems.  Illuminating the depth and breadth of lack of concern for patient well-being at DePuy, I encourage you to read… Continue Reading

2011 – More research associates pseudotumors with metal-on-metal hip replacements

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A 2011 article by YM Kwon et al. titled “‘Asymptomatic pseudotumors after metal-on-metal hip resurfacing arthroplasty: prevalence and metal ion study.” published in The Journal of Arthroplasty cites that “Symptomatic abnormal periprosthetic soft-tissue reactions (“pseudotumors”) have been reported after metal-on-metal hip resurfacing arthroplasty (MoMHRA).” Accordingly, the aims of this study were twofold: “(1) to determine… Continue Reading

2011 – Researchers link metal-on-metal hip replacements and pseudotumors

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In a 2011 article by NP Hailer et al. titled “Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal hip arthroplasty.” published in the medical journal Acta Orthopaedica, researchers state “Following metal-on-metal hip arthroplasty (THA), immunological reactions including changes in lymphocyte populations, aseptic loosening, and lymphocytic… Continue Reading

2011 – Study Shows: “Cup inclination, version angles” influence metal ion levels in metal-on-metal hip replacement

Posted in DePuy Hip Replacement

In a 2011 report by AJ Hart et al. published in Clinical Orthopaedics and Related Research, researchers write “Many factors affect the blood metal ion levels after metal-on-metal (MOM) hip arthroplasty” and “The main surgically adjustable variable is the amount of coverage of the head provided by the cup which is a function of the… Continue Reading

2006 – Canadian Research Team “Concerned” With Metal-on-Metal Hip Use

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In 2006, the government-mandated Canadian organization Health Quality Ontario published the results of a study in Ontario Health Technology Assessment Series that aimed to “assess the safety and effectiveness of metal on metal (MOM) hip resurfacing arthroplasty for young patients compared with that of total hip replacement (THR) in the same population.” This study, titled… Continue Reading

2012 – Metal-on-metal hip replacements linked to high revision rate

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A 2012 report by AJ Smith et al. titled “Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the National Joint Registry of England and Wales.” published in the prominent medical journal The Lancet aimed to “assess if metal-on-metal bearing surfaces lead to increased implant survival compared with other bearing surfaces in stemmed… Continue Reading

2011 – DePuy ASR failure rate 12% at 5 years

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In 2011, an article published by R. Underwood et al. in Journal of Bone and Joint Surgery titled “A comparison of explanted Articular Surface Replacement and Birmingham Hip Resurfacing components.” evaluated the relative safety and efficacy of the DePuy ASR hip replacement as compared to Birmingham Hip Resurfacing components. In recent years, a number of… Continue Reading

2011 – More than 25% of DePuy ASR users suffer elevated blood metal ion levels, premature device failure

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Citing that “There is widespread concern regarding the incidence of adverse soft-tissue reactions after metal-on-metal (MoM) hip replacement” and “Recent National Joint Registry data have shown clear differences in the rates of failure of different designs of hip resurfacing,” a study by DJ Langton et al. (2011) aimed to “update the failure rates related to… Continue Reading

2012 – DePuy ASR has “inferior outcome with higher revision risk”

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Published in 2012, an article by M. Seppänen et al. titled “Hip resurfacing arthroplasty: short-term survivorship of 4,401 hips from the Finnish Arthroplasty Register.” aimed to determine the short-term reliability of a variety of hip resurfacings used in 4,401 Finnish citizens, as compared to the reliability seen in 48,409  total hip arthroplasty procedures during the… Continue Reading

2012 – UK study shows DePuy ASR fails 2.82 times more often than standard

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In 2012, SS Jameson et al. published a study aiming to determine factors predictive of revision (replacement) of metal-on-metal hip implants.  That study appears in the June edition of Journal of Bone and Joint Surgery, and is titled, understandably, “Independent predictors of revision following metal-on-metal hip resurfacing: a retrospective cohort study using National Joint Registry… Continue Reading

2013 – DePuy ASR found six times as likely to fail as other metal-on-metal hip replacements

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DePuy ASR metal-on-metal hip implants are frequently associated with premature device failure requiring revision (this prompted the recall of the ASR/ASRXL models in 2010) and femoral fracture.  Much of the more recent research deals with the ASR complication of metal dissemination – the wearing off of tiny metal particles from the implants that enter the… Continue Reading

2013 – High rate of failure associated with DePuy ASR hip replacements

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Here is an excerpt from the abstract of a 2013 article published in Clinical Orthopaedics and Related Research by KT Hug et al.: “The Articular Surface Replacement™ (ASR™) metal-on-metal hip arthroplasty system (DePuy Orthopaedics, Inc, Warsaw, IN, USA) reportedly has a higher than anticipated early failure rate leading to a voluntary recall. This prompted us… Continue Reading

UK Research Team Finds DePuy ASR 5-year Failure Rate at 19%

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In 2012, GS Whitwell et al. published a report in the medical journal Hip International titled “The articular surface replacement implant recall: a United Kingdom district hospital experience.” summarizing the experience of one hospital after the 2010 DePuy ASR recall. At the time of the ASR recall in 2010, 111 of 121 recently implanted DePuy… Continue Reading